ID   CONO_CONTE              Reviewed;           8 AA.
AC   P86255;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   22-APR-2020, entry version 25.
DE   RecName: Full=Conopressin-Tx {ECO:0000305};
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, DISULFIDE BOND, HYDROXYLATION AT
RP   PRO-7, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=19380747; DOI=10.1073/pnas.0900745106;
RA   Ueberheide B.M., Fenyo D., Alewood P.F., Chait B.T.;
RT   "Rapid sensitive analysis of cysteine rich peptide venom components.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:6910-6915(2009).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=22709442; DOI=10.1021/pr300312h;
RA   Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA   Yates J.R. III, Bern M.;
RT   "Constrained de novo sequencing of conotoxins.";
RL   J. Proteome Res. 11:4191-4200(2012).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, POSITION IN VENOM
RP   DUCT, AND HYDROXYLATION AT PRO-7.
RC   TISSUE=Venom;
RX   PubMed=23031820; DOI=10.1016/j.toxicon.2012.09.013;
RA   Dobson R., Collodoro M., Gilles N., Turtoi A., De Pauw E., Quinton L.;
RT   "Secretion and maturation of conotoxins in the venom ducts of Conus
RT   textile.";
RL   Toxicon 60:1370-1379(2012).
CC   -!- FUNCTION: Targets vasopressin-oxytocin related receptors.
CC       {ECO:0000250|UniProtKB:P0DL76}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19380747,
CC       ECO:0000269|PubMed:22709442, ECO:0000269|PubMed:23031820}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. Is present in all duct
CC       parts with a highest content in the proximal part (part 1) (27%), part
CC       2 (29%), and the distal part (part 5) (26%).
CC       {ECO:0000305|PubMed:19380747, ECO:0000305|PubMed:23031820}.
CC   -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=962.411; Mass_error=0.02; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:19380747};
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000255}.
CC   -!- CAUTION: According to a report, a hydroxyproline is present at position
CC       8 (PubMed:22709442). According to other publications, a hydroxyproline
CC       is present at position 7 (PubMed:19380747, PubMed:23031820).
CC       {ECO:0000269|PubMed:19380747, ECO:0000269|PubMed:22709442,
CC       ECO:0000269|PubMed:23031820}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   ConoServer; 3726; conopressin-Tx.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond;
KW   G-protein coupled receptor impairing toxin; Hydroxylation; Secreted; Toxin.
FT   PEPTIDE         1..8
FT                   /note="Conopressin-Tx"
FT                   /evidence="ECO:0000269|PubMed:19380747"
FT                   /id="PRO_0000371263"
FT   MOD_RES         7
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:19380747,
FT                   ECO:0000269|PubMed:23031820"
FT   DISULFID        1..6
FT                   /evidence="ECO:0000269|PubMed:19380747"
FT   UNSURE          3
FT                   /note="I or L"
FT                   /evidence="ECO:0000305|PubMed:19380747"
SQ   SEQUENCE   8 AA;  949 MW;  D8776EB4540059CE CRC64;
     CFIRNCPP