ID   CONO_LYMST              Reviewed;         155 AA.
AC   Q00945;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Conopressin/neurophysin;
DE   Contains:
DE     RecName: Full=Lys-conopressin G;
DE   Contains:
DE     RecName: Full=Neurophysin;
DE   Flags: Precursor;
OS   Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Lymnaeidae; Lymnaea.
OX   NCBI_TaxID=6523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 27-35.
RC   TISSUE=CNS;
RX   PubMed=1584795; DOI=10.1073/pnas.89.10.4593;
RA   van Kesteren R.E., Smit A.B., Dirks R.W., de With N.D., Geraerts W.P.M.,
RA   Joosse J.;
RT   "Evolution of the vasopressin/oxytocin superfamily: characterization of a
RT   cDNA encoding a vasopressin-related precursor, preproconopressin, from the
RT   mollusc Lymnaea stagnalis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:4593-4597(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7666183; DOI=10.1523/jneurosci.15-09-05989.1995;
RA   van Kesteren R.E., Smit A.B., de Lange R.P., Kits K.S., Golen F.A.,
RA   der Schors R.C., de With N.D., Burke J.F., Geraerts W.P.M.;
RT   "Structural and functional evolution of the vasopressin/oxytocin
RT   superfamily: vasopressin-related conopressin is the only member present in
RT   Lymnaea, and is involved in the control of sexual behavior.";
RL   J. Neurosci. 15:5989-5998(1995).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC   -!- PTM: Seven disulfide bonds are present in neurophysin.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   EMBL; M86610; AAA29289.1; -; mRNA.
DR   EMBL; S79473; AAB35220.1; -; Genomic_DNA.
DR   EMBL; S79471; AAB35220.1; JOINED; Genomic_DNA.
DR   EMBL; S79472; AAB35220.1; JOINED; Genomic_DNA.
DR   PIR; A45293; A45293.
DR   AlphaFoldDB; Q00945; -.
DR   SMR; Q00945; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   Gene3D; 2.60.9.10; -; 1.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR036387; Neurhyp_horm_dom_sf.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PANTHER; PTHR11681; PTHR11681; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   SMART; SM00003; NH; 1.
DR   SUPFAM; SSF49606; SSF49606; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:1584795"
FT   PEPTIDE         27..35
FT                   /note="Lys-conopressin G"
FT                   /id="PRO_0000020570"
FT   CHAIN           39..155
FT                   /note="Neurophysin"
FT                   /id="PRO_0000020571"
FT   MOD_RES         35
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..32
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        50..94
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        53..67
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        61..84
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        68..74
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        101..115
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        109..127
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
FT   DISULFID        116..121
FT                   /evidence="ECO:0000250|UniProtKB:P01175"
SQ   SEQUENCE   155 AA;  16197 MW;  6639BCB24BCA32A3 CRC64;
     MMSSLCGMPL TYLLTAAVLS LSLTDACFIR NCPKGGKRSL DTGMVTSREC MKCGPGGTGQ
     CVGPSICCGQ DFGCHVGTAE AAVCQQENDS STPCLVKGEA CGSRDAGNCV ADGICCDSES
     CAVNDRCRDL DGNAQANRGD LIQLIHKLLK VRDYD