ID   COPA2_ECOLX             Reviewed;          61 AA.
AC   P13946;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Protein CopA/IncA;
DE   AltName: Full=Protein RepA3;
GN   Name=copA; Synonyms=incA, repA3;
OS   Escherichia coli.
OG   Plasmid R6-5, Plasmid IncFII R100 (NR1), and
OG   Plasmid IncFII R1-19 (R1 drd-19).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=R6-5;
RX   PubMed=7029525; DOI=10.1073/pnas.78.8.4699;
RA   Danbara H., Brady G., Timmis J.K., Timmis K.N.;
RT   "Regulation of DNA replication: 'target' determinant of the replication
RT   control elements of plasmid R6-5 lies within a control element gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4699-4703(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=R6-5;
RX   PubMed=6187730; DOI=10.1128/jb.154.1.429-436.1983;
RA   Brady G., Frey J., Danbara H., Timmis K.N.;
RT   "Replication control mutations of plasmid R6-5 and their effects on
RT   interactions of the RNA-I control element with its target.";
RL   J. Bacteriol. 154:429-436(1983).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=IncFII R100 (NR1);
RX   PubMed=2580099; DOI=10.1016/0022-2836(85)90228-1;
RA   Womble D.D., Sampathkumar P., Easton A.M., Luckow V.A., Rownd R.H.;
RT   "Transcription of the replication control region of the IncFII R-plasmid
RT   NR1 in vitro and in vivo.";
RL   J. Mol. Biol. 181:395-410(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=IncFII R1-19 (R1 drd-19);
RX   PubMed=6261081; DOI=10.1007/bf00339014;
RA   Stougaard P., Molin S., Nordstroem K., Hansen F.G.;
RT   "The nucleotide sequence of the replication control region of the
RT   resistance plasmid R1drd-19.";
RL   Mol. Gen. Genet. 181:116-122(1981).
CC   -!- FUNCTION: Controls the copy number in gene replication.
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DR   EMBL; V00318; CAA23609.1; -; Genomic_DNA.
DR   EMBL; V00319; CAA23610.1; -; Genomic_DNA.
DR   EMBL; X02302; CAA26167.1; -; Genomic_DNA.
DR   EMBL; V00326; CAA23617.1; -; Genomic_DNA.
DR   RefSeq; WP_012615301.1; NC_025106.1.
DR   RefSeq; YP_002456234.1; NC_011812.1.
DR   RefSeq; YP_003108324.1; NC_013122.1.
DR   RefSeq; YP_004869997.1; NC_016039.1.
DR   RefSeq; YP_006952183.1; NC_019057.1.
DR   RefSeq; YP_006953266.1; NC_019071.1.
DR   RefSeq; YP_006953364.1; NC_019072.1.
DR   RefSeq; YP_006953886.1; NC_019090.1.
DR   RefSeq; YP_006990698.1; NC_019424.1.
DR   RefSeq; YP_007447500.1; NC_020278.2.
DR   RefSeq; YP_009066514.1; NC_025106.1.
DR   AlphaFoldDB; P13946; -.
DR   GO; GO:0006276; P:plasmid maintenance; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Plasmid; Plasmid copy control.
FT   CHAIN           1..61
FT                   /note="Protein CopA/IncA"
FT                   /id="PRO_0000068289"
SQ   SEQUENCE   61 AA;  7252 MW;  7D0B295459C33A1D CRC64;
     MWIYRSQKSK NPDNLLQLWR VRKDYRGPLK PYSQQFSYAG SIVICPEKFK TSFCARSFCA
     L