ID   ACPM_MYCLE              Reviewed;         115 AA.
AC   O69475;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Meromycolate extension acyl carrier protein;
DE            Short=ACP;
GN   Name=acpM; OrderedLocusNames=ML1654; ORFNames=MLCB1243.21c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Acyl carrier protein involved in meromycolate extension.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific serine
CC       of apo-AcpM. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the acyl carrier protein (ACP) family.
CC       {ECO:0000305}.
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DR   EMBL; AL023635; CAA19202.1; -; Genomic_DNA.
DR   EMBL; AL583922; CAC30605.1; -; Genomic_DNA.
DR   PIR; T44712; T44712.
DR   RefSeq; NP_302135.1; NC_002677.1.
DR   RefSeq; WP_010908456.1; NC_002677.1.
DR   AlphaFoldDB; O69475; -.
DR   SMR; O69475; -.
DR   STRING; 272631.ML1654; -.
DR   EnsemblBacteria; CAC30605; CAC30605; CAC30605.
DR   KEGG; mle:ML1654; -.
DR   PATRIC; fig|272631.5.peg.3121; -.
DR   Leproma; ML1654; -.
DR   eggNOG; COG0236; Bacteria.
DR   HOGENOM; CLU_108696_5_6_11; -.
DR   OMA; CEIPDEQ; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000036; F:acyl carrier activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   HAMAP; MF_01217; Acyl_carrier; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR003231; Acyl_carrier.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   PANTHER; PTHR20863; PTHR20863; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Phosphopantetheine; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..115
FT                   /note="Meromycolate extension acyl carrier protein"
FT                   /id="PRO_0000180244"
FT   DOMAIN          3..81
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         41
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   115 AA;  12515 MW;  996E93E89818AF50 CRC64;
     MAVTQEEIIA GIAEIIEEVT GIEPSEITPE KSFVDDLDID SLSMVEIAVQ TEDKYGVKIP
     DEDLAGLRTV GDVVTYIQKL EEENPEAAEA LRAKIVSENP EAAANVQARL ETESK