ACPR1_AEDAE
ID ACPR1_AEDAE Reviewed; 577 AA.
AC A0A2L0VBG2;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 25-APR-2018, sequence version 1.
DT 23-FEB-2022, entry version 13.
DE RecName: Full=Adipokinetic hormone/corazonin-related peptide receptor variant I {ECO:0000303|PubMed:29391531};
DE Short=ACP receptor 1 {ECO:0000303|PubMed:29391531, ECO:0000305};
DE Short=ACPR-I {ECO:0000303|PubMed:29391531};
DE AltName: Full=ACPr1 {ECO:0000312|EMBL:AVA08868.1};
DE AltName: Full=GnRH-related neuropeptide receptor;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=29391531; DOI=10.1038/s41598-018-20517-8;
RA Wahedi A., Paluzzi J.P.;
RT "Molecular identification, transcript expression, and functional
RT deorphanization of the adipokinetic hormone/corazonin-related peptide
RT receptor in the disease vector, Aedes aegypti.";
RL Sci. Rep. 8:2146-2146(2018).
CC -!- FUNCTION: G-protein coupled receptor specific for adipokinetic
CC hormone/corazonin-related peptide (ACP) (EC(50)=10.25 nM). Is not
CC activated by the closely related peptides AKH and CRZ, or other tested
CC peptides. {ECO:0000269|PubMed:29391531}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Highly expressed in abdominal ganglia, and also
CC observed in the carcass, accessory reproductive tissue, testes, head,
CC hindgut, and thoracic ganglia of adult mosquitoes. Is more expressed in
CC adult males than in females. {ECO:0000269|PubMed:29391531}.
CC -!- DEVELOPMENTAL STAGE: Much more expressed in adults than in larvae.
CC {ECO:0000269|PubMed:29391531}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000305}.
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DR EMBL; MF461644; AVA08868.1; -; mRNA.
DR SMR; A0A2L0VBG2; -.
DR VEuPathDB; VectorBase:AAEL019491; -.
DR Proteomes; UP000008820; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..577
FT /note="Adipokinetic hormone/corazonin-related peptide
FT receptor variant I"
FT /evidence="ECO:0000305|PubMed:29391531"
FT /id="PRO_0000453423"
FT TOPO_DOM 1..108
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 109..129
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 142..162
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..181
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 182..202
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..223
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 224..244
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..275
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 276..296
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 342..362
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..377
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 378..398
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT REGION 409..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 180..258
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 577 AA; 63337 MW; FAF8E18E6F0FBB6C CRC64;
MYLSAGLRKI MDNPPVTSKY QHRSQDEMLS ANLNHQQTTN GSPSTTMMLG GDAAAVAFAS
SSSNGAGDAY FRGLAALTGN ASGISSMDMS NSTETGIVAP GHTETTVAVI IVYCVLFIIA
AGGNLSVVIT LFRSRRHRRS RVSLMICHLA VADLMVAFIM IPLEVGWRIT VQWHAGNVAC
KVFLFMRAFC LYLSSNVLVC VSLDRCFAVI YPLRVSAARK RGKIMLGGAW FIAFANAIPQ
SIIFRVQHHP NVPDFTQCVT FGFFTTPAME TAYNLFCVVA MYFMPLMVIS AAYTVILCEI
SNRSREKETS DTSHTGGMRL RCNDLTHIER ARQRTLRLTI TIVVVFVWCW TPYVVMTLWY
MFDRESALKV DGAIQDGLFL MAVSNSCMNP LVYGSYAMKC RRPWRRQMAP NGVQTPNAAQ
RRSTDAVSGM VGPHSDRLTG RDNKDELVYE GGGTERNKLK QFGMANGIFA RIGSTGRNHV
TMAGGGAAGT SVATTRFGNC TTTVGGRNVT EPIRTVAMSS GSRVKSFQPS YSEFVMMADE
RSLMLSRPSF YSDPTPNEFD STVDCGLTRS LDTGGWR
