ID   COPP_HELPJ              Reviewed;          66 AA.
AC   Q9ZM70;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=COP-associated protein;
DE   AltName: Full=Copper ion-binding protein;
GN   Name=copP; OrderedLocusNames=jhp_0352;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Part of a cation-transporting system which is associated with
CC       copper export out of the H.pylori cells.
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DR   EMBL; AE001439; AAD05936.1; -; Genomic_DNA.
DR   PIR; H71940; H71940.
DR   RefSeq; WP_000869072.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZM70; -.
DR   SMR; Q9ZM70; -.
DR   STRING; 85963.jhp_0352; -.
DR   EnsemblBacteria; AAD05936; AAD05936; jhp_0352.
DR   KEGG; hpj:jhp_0352; -.
DR   PATRIC; fig|85963.30.peg.659; -.
DR   eggNOG; COG2608; Bacteria.
DR   OMA; MKVTFQV; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0006825; P:copper ion transport; IEA:InterPro.
DR   CDD; cd00371; HMA; 1.
DR   InterPro; IPR000428; Cu-bd.
DR   InterPro; IPR017969; Heavy-metal-associated_CS.
DR   InterPro; IPR006122; HMA_Cu_ion-bd.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   Pfam; PF00403; HMA; 1.
DR   PRINTS; PR00944; CUEXPORT.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   TIGRFAMs; TIGR00003; TIGR00003; 1.
DR   PROSITE; PS01047; HMA_1; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   4: Predicted;
KW   Copper; Metal-binding.
FT   CHAIN           1..66
FT                   /note="COP-associated protein"
FT                   /id="PRO_0000079245"
FT   DOMAIN          1..66
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         12
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         15
FT                   /ligand="Cu cation"
FT                   /ligand_id="ChEBI:CHEBI:23378"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
SQ   SEQUENCE   66 AA;  7226 MW;  34CEDD39289816E6 CRC64;
     MKVTFQVPSI TCNHCVDKIE KFVGEIEGVS FIDASVEKKS VVVEFDTPAT QDLIKEALLD
     AGQEVV