ID   COPT1_ORYSJ             Reviewed;         161 AA.
AC   Q94EE4; A0A0P0V8P7; Q0JIY5;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Copper transporter 1;
DE            Short=OsCOPT1;
GN   Name=COPT1; OrderedLocusNames=Os01g0770700, LOC_Os01g56420;
GN   ORFNames=P0665A11.22;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   FUNCTION, INTERACTION WITH SWEET11 AND COPT2, SUBCELLULAR LOCATION, AND
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Mudanjiang 8, and cv. Zhonghua 11;
RX   PubMed=20852017; DOI=10.1105/tpc.110.078022;
RA   Antony G., Zhou J., Huang S., Li T., Liu B., White F., Yang B., Yuan M.,
RA   Chu Z., Li X., Xu C., Wang S.;
RT   "Rice xa13 recessive resistance to bacterial blight is defeated by
RT   induction of the disease susceptibility gene Os-11N3. The bacterial
RT   pathogen Xanthomonas oryzae overcomes rice defenses by regulating host
RT   copper redistribution.";
RL   Plant Cell 22:3164-3176(2010).
CC   -!- FUNCTION: Involved in the transport of copper, in cooperation with
CC       SWEET11 and COPT2. Contributes to the removal of copper (Cu) from
CC       xylem, and thus to the sensitivity toward bacterial pathogens such as
CC       X.oryzae pv. oryzae (Xoo). {ECO:0000269|PubMed:20852017}.
CC   -!- SUBUNIT: Self-interacts. Interacts with SWEET11 and COPT2.
CC       {ECO:0000269|PubMed:20852017}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20852017};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:20852017}.
CC   -!- DISRUPTION PHENOTYPE: Reduced copper transport ability, increase in
CC       copper content of the xylem, and enhanced resistance against X.oryzae
CC       pv. oryzae (Xoo) PXO99. {ECO:0000269|PubMed:20852017}.
CC   -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC       SLC31A subfamily. {ECO:0000305}.
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DR   EMBL; AP003106; BAB56072.1; -; Genomic_DNA.
DR   EMBL; AP008207; BAF06293.2; -; Genomic_DNA.
DR   EMBL; AP014957; BAS74550.1; -; Genomic_DNA.
DR   RefSeq; XP_015630809.1; XM_015775323.1.
DR   AlphaFoldDB; Q94EE4; -.
DR   SMR; Q94EE4; -.
DR   STRING; 4530.OS01T0770700-00; -.
DR   PaxDb; Q94EE4; -.
DR   PRIDE; Q94EE4; -.
DR   EnsemblPlants; Os01t0770700-00; Os01t0770700-00; Os01g0770700.
DR   GeneID; 4324610; -.
DR   Gramene; Os01t0770700-00; Os01t0770700-00; Os01g0770700.
DR   KEGG; osa:4324610; -.
DR   eggNOG; KOG3386; Eukaryota.
DR   HOGENOM; CLU_079690_1_0_1; -.
DR   InParanoid; Q94EE4; -.
DR   OMA; MAWTNDN; -.
DR   OrthoDB; 1389393at2759; -.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   Genevisible; Q94EE4; OS.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:UniProtKB.
DR   GO; GO:0043621; F:protein self-association; IDA:UniProtKB.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006825; P:copper ion transport; IMP:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR007274; Cop_transporter.
DR   PANTHER; PTHR12483; PTHR12483; 1.
DR   Pfam; PF04145; Ctr; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Copper; Copper transport; Ion transport; Membrane;
KW   Plant defense; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..161
FT                   /note="Copper transporter 1"
FT                   /id="PRO_0000399998"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   161 AA;  16677 MW;  255C441DCA710B29 CRC64;
     MDMGGHDMGG MSPPAAGAAA QGGMGAMKSM RYTHMTFFWG KNSEVLFTMW PGTRGGMYAL
     ALIFVFALAV IVEFLGSRRA DACLAALARR APAAGGLARA AVHTVRVGVA YLLMLALMSF
     NGGVFLVAVA GHAAGFLAFR AGLCGGPAQV EEDRKNDPAC C