COPT1_PIG
ID COPT1_PIG Reviewed; 189 AA.
AC Q8WNR0;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=High affinity copper uptake protein 1;
DE AltName: Full=Copper transporter 1;
DE Short=CTR1;
DE AltName: Full=Solute carrier family 31 member 1;
GN Name=SLC31A1; Synonyms=CTR1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=12580789; DOI=10.1046/j.1365-2052.2003.00940.x;
RA Harboe T.L., Jensen L.R., Hansen C., Horn P., Bendixen C., Tommerup N.,
RA Tumer Z.;
RT "Cloning, characterization and chromosomal localization of the Sus scrofa
RT SLC31A1 gene.";
RL Anim. Genet. 34:59-61(2003).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=20699218; DOI=10.1074/jbc.m110.143826;
RA Nose Y., Wood L.K., Kim B.E., Prohaska J.R., Fry R.S., Spears J.W.,
RA Thiele D.J.;
RT "Ctr1 is an apical copper transporter in mammalian intestinal epithelial
RT cells in vivo that is controlled at the level of protein stability.";
RL J. Biol. Chem. 285:32385-32392(2010).
CC -!- FUNCTION: High-affinity, saturable copper transporter involved in
CC dietary copper uptake. {ECO:0000269|PubMed:20699218}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20699218};
CC Multi-pass membrane protein {ECO:0000269|PubMed:20699218}.
CC Note=Localizes to the apical membrane in intestinal epithelial cells.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000305}.
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DR EMBL; AF320815; AAL49494.1; -; mRNA.
DR EMBL; AY141204; AAN46363.1; -; Genomic_DNA.
DR EMBL; AY141203; AAN46363.1; JOINED; Genomic_DNA.
DR RefSeq; NP_999265.1; NM_214100.3.
DR AlphaFoldDB; Q8WNR0; -.
DR BMRB; Q8WNR0; -.
DR SMR; Q8WNR0; -.
DR STRING; 9823.ENSSSCP00000023413; -.
DR PaxDb; Q8WNR0; -.
DR PeptideAtlas; Q8WNR0; -.
DR Ensembl; ENSSSCT00000043438; ENSSSCP00000044266; ENSSSCG00000034278.
DR Ensembl; ENSSSCT00015025923; ENSSSCP00015010140; ENSSSCG00015019589.
DR Ensembl; ENSSSCT00025056789; ENSSSCP00025024011; ENSSSCG00025041899.
DR Ensembl; ENSSSCT00035102104; ENSSSCP00035043524; ENSSSCG00035075133.
DR Ensembl; ENSSSCT00040015505; ENSSSCP00040006097; ENSSSCG00040011811.
DR Ensembl; ENSSSCT00045050616; ENSSSCP00045035237; ENSSSCG00045029659.
DR Ensembl; ENSSSCT00050073856; ENSSSCP00050031823; ENSSSCG00050054168.
DR Ensembl; ENSSSCT00065023777; ENSSSCP00065009678; ENSSSCG00065017903.
DR Ensembl; ENSSSCT00070042714; ENSSSCP00070035928; ENSSSCG00070021475.
DR Ensembl; ENSSSCT00070042716; ENSSSCP00070035930; ENSSSCG00070021475.
DR GeneID; 397186; -.
DR KEGG; ssc:397186; -.
DR CTD; 1317; -.
DR VGNC; VGNC:103180; SLC31A1.
DR eggNOG; KOG3386; Eukaryota.
DR GeneTree; ENSGT00940000155147; -.
DR InParanoid; Q8WNR0; -.
DR OrthoDB; 1389393at2759; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Proteomes; UP000314985; Chromosome 1.
DR Bgee; ENSSSCG00000034278; Expressed in duodenum and 45 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR GO; GO:0015677; P:copper ion import; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483; PTHR12483; 1.
DR Pfam; PF04145; Ctr; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Copper; Copper transport; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..189
FT /note="High affinity copper uptake protein 1"
FT /id="PRO_0000290190"
FT TOPO_DOM 1..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..189
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 15..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 113
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O15431"
SQ SEQUENCE 189 AA; 20953 MW; C0327F7C5AE919B4 CRC64;
MDHSAHMGMS THMGMSDMNH STTMPPSHHH PTSSGSHESM MMPMTFYFGF KKVEVLFAGL
VINTAGEMAG AFVAVFLLAM FYEGLKIARE GLLRKSQVSI RYNSMPVPGP NGTILMETHK
TVGQQMLSFP HLLQTVLHII QVVISYFLML IFMTYNGYLC IAVAAGAGTG YFLFSWKKAV
VVDITEHCH
