COPT1_RAT
ID COPT1_RAT Reviewed; 187 AA.
AC Q9JK41; Q53YN6;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=High affinity copper uptake protein 1;
DE AltName: Full=Copper transporter 1;
DE Short=rCTR1;
DE AltName: Full=Liver regeneration-related protein LRRGT00200;
DE AltName: Full=Solute carrier family 31 member 1;
GN Name=Slc31a1; Synonyms=Copt1, Ctr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Chino H., Hiromura M., Sonoda T., Yasui H., Sakurai H.;
RT "Molecular cloning of rat copper transport protein 1.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RA Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M.,
RA Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=20699218; DOI=10.1074/jbc.m110.143826;
RA Nose Y., Wood L.K., Kim B.E., Prohaska J.R., Fry R.S., Spears J.W.,
RA Thiele D.J.;
RT "Ctr1 is an apical copper transporter in mammalian intestinal epithelial
RT cells in vivo that is controlled at the level of protein stability.";
RL J. Biol. Chem. 285:32385-32392(2010).
CC -!- FUNCTION: High-affinity, saturable copper transporter involved in
CC dietary copper uptake. {ECO:0000269|PubMed:20699218}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20699218};
CC Multi-pass membrane protein {ECO:0000269|PubMed:20699218}.
CC Note=Localizes to the apical membrane in intestinal epithelial cells.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000305}.
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DR EMBL; AF268030; AAF72546.1; -; mRNA.
DR EMBL; AY539951; AAS66291.1; -; mRNA.
DR EMBL; BC078745; AAH78745.1; -; mRNA.
DR RefSeq; NP_598284.1; NM_133600.1.
DR AlphaFoldDB; Q9JK41; -.
DR BMRB; Q9JK41; -.
DR SMR; Q9JK41; -.
DR STRING; 10116.ENSRNOP00000019544; -.
DR GlyGen; Q9JK41; 2 sites.
DR PhosphoSitePlus; Q9JK41; -.
DR jPOST; Q9JK41; -.
DR PaxDb; Q9JK41; -.
DR GeneID; 171135; -.
DR KEGG; rno:171135; -.
DR UCSC; RGD:620059; rat.
DR CTD; 1317; -.
DR RGD; 620059; Slc31a1.
DR VEuPathDB; HostDB:ENSRNOG00000014475; -.
DR eggNOG; KOG3386; Eukaryota.
DR HOGENOM; CLU_079690_2_0_1; -.
DR InParanoid; Q9JK41; -.
DR OMA; MNMIFTW; -.
DR OrthoDB; 1389393at2759; -.
DR PhylomeDB; Q9JK41; -.
DR Reactome; R-RNO-425410; Metal ion SLC transporters.
DR PRO; PR:Q9JK41; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000014475; Expressed in jejunum and 18 other tissues.
DR Genevisible; Q9JK41; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0055037; C:recycling endosome; ISO:RGD.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IDA:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0006878; P:cellular copper ion homeostasis; ISO:RGD.
DR GO; GO:0072719; P:cellular response to cisplatin; IDA:RGD.
DR GO; GO:0015677; P:copper ion import; IDA:RGD.
DR GO; GO:0098705; P:copper ion import across plasma membrane; IMP:RGD.
DR GO; GO:0055085; P:transmembrane transport; IDA:RGD.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483; PTHR12483; 1.
DR Pfam; PF04145; Ctr; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Copper; Copper transport; Glycoprotein; Ion transport;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..187
FT /note="High affinity copper uptake protein 1"
FT /id="PRO_0000195042"
FT TOPO_DOM 1..65
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..129
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..153
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 111
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O15431"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 187 AA; 21129 MW; 05CA4A45A543F5D1 CRC64;
MRMNHMEMHH MGMNHTDDNI TMPPHQHPTT SASHSHEMMM PMTFYFGFKN VDLLFSSLVI
NTPGEMAGAF VAVFLLAMFY EGLKIAREGL LRKSQVSIRY NSMPVPGPNG TILMETHKTV
GQQMLSFPHL LQTVLHIIQV VISYFLMLIF MTYNGYLCIA VAAGAGTGYF LFSWKKAVVV
DITEHCH
