ID   COPT2_ARATH             Reviewed;         158 AA.
AC   Q9STG2;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Copper transporter 2;
DE            Short=AtCOPT2;
GN   Name=COPT2; OrderedLocusNames=At3g46900; ORFNames=T6H20.70;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   FUNCTION, TISSUE SPECIFICITY, INDUCTION, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12650623; DOI=10.1023/a:1022345507112;
RA   Sancenon V., Puig S., Mira H., Thiele D.J., Penarrubia L.;
RT   "Identification of a copper transporter family in Arabidopsis thaliana.";
RL   Plant Mol. Biol. 51:577-587(2003).
RN   [5]
RP   INDUCTION.
RX   PubMed=20117084; DOI=10.1016/j.bbrc.2010.01.111;
RA   del Pozo T., Cambiazo V., Gonzalez M.;
RT   "Gene expression profiling analysis of copper homeostasis in Arabidopsis
RT   thaliana.";
RL   Biochem. Biophys. Res. Commun. 393:248-252(2010).
CC   -!- FUNCTION: Involved in the transport of copper.
CC       {ECO:0000269|PubMed:12650623}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in leaves and at lower levels in
CC       roots, stems and flowers. {ECO:0000269|PubMed:12650623}.
CC   -!- INDUCTION: By copper deficiency. Down-regulated by treatment with high
CC       concentrations of copper. {ECO:0000269|PubMed:12650623,
CC       ECO:0000269|PubMed:20117084}.
CC   -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC       SLC31A subfamily. {ECO:0000305}.
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DR   EMBL; AL096859; CAB51175.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE78216.1; -; Genomic_DNA.
DR   EMBL; AF466370; AAL74262.1; -; mRNA.
DR   EMBL; BT009708; AAP88342.1; -; mRNA.
DR   PIR; T12958; T12958.
DR   RefSeq; NP_190274.1; NM_114557.3.
DR   AlphaFoldDB; Q9STG2; -.
DR   SMR; Q9STG2; -.
DR   BioGRID; 9163; 12.
DR   IntAct; Q9STG2; 10.
DR   STRING; 3702.AT3G46900.1; -.
DR   PaxDb; Q9STG2; -.
DR   PRIDE; Q9STG2; -.
DR   ProteomicsDB; 241170; -.
DR   EnsemblPlants; AT3G46900.1; AT3G46900.1; AT3G46900.
DR   GeneID; 823843; -.
DR   Gramene; AT3G46900.1; AT3G46900.1; AT3G46900.
DR   KEGG; ath:AT3G46900; -.
DR   Araport; AT3G46900; -.
DR   TAIR; locus:2102752; AT3G46900.
DR   eggNOG; KOG3386; Eukaryota.
DR   HOGENOM; CLU_079690_1_2_1; -.
DR   InParanoid; Q9STG2; -.
DR   OMA; PHMMMMH; -.
DR   OrthoDB; 1389393at2759; -.
DR   PhylomeDB; Q9STG2; -.
DR   PRO; PR:Q9STG2; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9STG2; baseline and differential.
DR   Genevisible; Q9STG2; AT.
DR   GO; GO:0046658; C:anchored component of plasma membrane; HDA:TAIR.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005375; F:copper ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015089; F:high-affinity copper ion transmembrane transporter activity; IGI:TAIR.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR   GO; GO:0098705; P:copper ion import across plasma membrane; IGI:TAIR.
DR   InterPro; IPR007274; Cop_transporter.
DR   PANTHER; PTHR12483; PTHR12483; 1.
DR   Pfam; PF04145; Ctr; 2.
PE   2: Evidence at transcript level;
KW   Copper; Copper transport; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..158
FT                   /note="Copper transporter 2"
FT                   /id="PRO_0000399993"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   158 AA;  17058 MW;  0CA9B1167F7E7AF3 CRC64;
     MDHDHMHDMP PPSPSSSSMS NHTTPHMMMM HMTFFWGKNT EVLFSGWPGT SSGMYALCLI
     VIFLLAVIAE WLAHSPILRV SGSTNRAAGL AQTAVYTLKT GLSYLVMLAV MSFNAGVFIV
     AIAGYGVGFF LFGSTTFKKP SDDQKTAELL PPSSGCVC