COPT2_HUMAN
ID COPT2_HUMAN Reviewed; 143 AA.
AC O15432;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Probable low affinity copper uptake protein 2;
DE AltName: Full=Copper transporter 2;
DE Short=hCTR2;
DE AltName: Full=Solute carrier family 31 member 2;
GN Name=SLC31A2; Synonyms=COPT2, CTR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9207117; DOI=10.1073/pnas.94.14.7481;
RA Zhou B., Gitschier J.;
RT "hCTR1: a human gene for copper uptake identified by complementation in
RT yeast.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:7481-7486(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
CC -!- FUNCTION: Involved in low-affinity copper uptake. {ECO:0000305}.
CC -!- INTERACTION:
CC O15432; Q12983: BNIP3; NbExp=3; IntAct=EBI-17867220, EBI-749464;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U83461; AAB66307.1; -; mRNA.
DR EMBL; BC026252; AAH26252.1; -; mRNA.
DR CCDS; CCDS6788.1; -.
DR RefSeq; NP_001851.1; NM_001860.2.
DR AlphaFoldDB; O15432; -.
DR SMR; O15432; -.
DR BioGRID; 107713; 36.
DR IntAct; O15432; 5.
DR MINT; O15432; -.
DR STRING; 9606.ENSP00000259392; -.
DR DrugBank; DB00958; Carboplatin.
DR DrugBank; DB00515; Cisplatin.
DR DrugBank; DB09130; Copper.
DR TCDB; 1.A.56.1.9; the copper transporter (ctr) family.
DR iPTMnet; O15432; -.
DR PhosphoSitePlus; O15432; -.
DR BioMuta; SLC31A2; -.
DR MassIVE; O15432; -.
DR PaxDb; O15432; -.
DR PeptideAtlas; O15432; -.
DR PRIDE; O15432; -.
DR ProteomicsDB; 48658; -.
DR Antibodypedia; 3100; 116 antibodies from 14 providers.
DR CPTC; O15432; 3 antibodies.
DR DNASU; 1318; -.
DR Ensembl; ENST00000259392.8; ENSP00000259392.3; ENSG00000136867.11.
DR GeneID; 1318; -.
DR KEGG; hsa:1318; -.
DR MANE-Select; ENST00000259392.8; ENSP00000259392.3; NM_001860.3; NP_001851.1.
DR CTD; 1318; -.
DR DisGeNET; 1318; -.
DR GeneCards; SLC31A2; -.
DR HGNC; HGNC:11017; SLC31A2.
DR HPA; ENSG00000136867; Group enriched (parathyroid gland, salivary gland).
DR MIM; 603088; gene.
DR neXtProt; NX_O15432; -.
DR OpenTargets; ENSG00000136867; -.
DR PharmGKB; PA35886; -.
DR VEuPathDB; HostDB:ENSG00000136867; -.
DR eggNOG; KOG3386; Eukaryota.
DR GeneTree; ENSGT00940000159996; -.
DR HOGENOM; CLU_079690_2_1_1; -.
DR InParanoid; O15432; -.
DR OMA; FWNVHSP; -.
DR OrthoDB; 1389393at2759; -.
DR PhylomeDB; O15432; -.
DR TreeFam; TF315142; -.
DR PathwayCommons; O15432; -.
DR SignaLink; O15432; -.
DR BioGRID-ORCS; 1318; 19 hits in 1079 CRISPR screens.
DR GeneWiki; SLC31A2; -.
DR GenomeRNAi; 1318; -.
DR Pharos; O15432; Tbio.
DR PRO; PR:O15432; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; O15432; protein.
DR Bgee; ENSG00000136867; Expressed in parotid gland and 192 other tissues.
DR ExpressionAtlas; O15432; baseline and differential.
DR Genevisible; O15432; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR GO; GO:0006825; P:copper ion transport; TAS:ProtInc.
DR GO; GO:1902311; P:regulation of copper ion transmembrane transport; IEA:Ensembl.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483; PTHR12483; 1.
DR Pfam; PF04145; Ctr; 1.
PE 1: Evidence at protein level;
KW Copper; Copper transport; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..143
FT /note="Probable low affinity copper uptake protein 2"
FT /id="PRO_0000195043"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CPU9"
SQ SEQUENCE 143 AA; 15681 MW; 0145EE8BE623443E CRC64;
MAMHFIFSDT AVLLFDFWSV HSPAGMALSV LVLLLLAVLY EGIKVGKAKL LNQVLVNLPT
SISQQTIAET DGDSAGSDSF PVGRTHHRWY LCHFGQSLIH VIQVVIGYFI MLAVMSYNTW
IFLGVVLGSA VGYYLAYPLL STA
