COPT2_MOUSE
ID COPT2_MOUSE Reviewed; 143 AA.
AC Q9CPU9;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Probable low affinity copper uptake protein 2;
DE AltName: Full=Copper transporter 2;
DE Short=CTR2;
DE AltName: Full=Solute carrier family 31 member 2;
GN Name=Slc31a2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Bates K.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-75 AND SER-77, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in low-affinity copper uptake. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC SLC31A subfamily. {ECO:0000305}.
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DR EMBL; AK008473; BAB25688.1; -; mRNA.
DR EMBL; AK003269; BAB22682.1; -; mRNA.
DR EMBL; AK007579; BAB25117.1; -; mRNA.
DR EMBL; AL683829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029183; AAH29183.1; -; mRNA.
DR CCDS; CCDS18236.1; -.
DR RefSeq; NP_001277447.1; NM_001290518.1.
DR RefSeq; NP_079562.1; NM_025286.3.
DR AlphaFoldDB; Q9CPU9; -.
DR SMR; Q9CPU9; -.
DR BioGRID; 203309; 2.
DR STRING; 10090.ENSMUSP00000081578; -.
DR iPTMnet; Q9CPU9; -.
DR PhosphoSitePlus; Q9CPU9; -.
DR jPOST; Q9CPU9; -.
DR MaxQB; Q9CPU9; -.
DR PaxDb; Q9CPU9; -.
DR PRIDE; Q9CPU9; -.
DR ProteomicsDB; 283791; -.
DR Antibodypedia; 3100; 116 antibodies from 14 providers.
DR DNASU; 20530; -.
DR Ensembl; ENSMUST00000084530; ENSMUSP00000081578; ENSMUSG00000066152.
DR GeneID; 20530; -.
DR KEGG; mmu:20530; -.
DR UCSC; uc008tee.2; mouse.
DR CTD; 1318; -.
DR MGI; MGI:1333844; Slc31a2.
DR VEuPathDB; HostDB:ENSMUSG00000066152; -.
DR eggNOG; KOG3386; Eukaryota.
DR GeneTree; ENSGT00940000159996; -.
DR InParanoid; Q9CPU9; -.
DR OMA; FWNVHSP; -.
DR OrthoDB; 1389393at2759; -.
DR PhylomeDB; Q9CPU9; -.
DR TreeFam; TF315142; -.
DR BioGRID-ORCS; 20530; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Slc31a2; mouse.
DR PRO; PR:Q9CPU9; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CPU9; protein.
DR Bgee; ENSMUSG00000066152; Expressed in lacrimal gland and 214 other tissues.
DR ExpressionAtlas; Q9CPU9; baseline and differential.
DR Genevisible; Q9CPU9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IDA:MGI.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055037; C:recycling endosome; IDA:MGI.
DR GO; GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902311; P:regulation of copper ion transmembrane transport; IMP:MGI.
DR InterPro; IPR007274; Cop_transporter.
DR PANTHER; PTHR12483; PTHR12483; 1.
DR Pfam; PF04145; Ctr; 1.
PE 1: Evidence at protein level;
KW Copper; Copper transport; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..143
FT /note="Probable low affinity copper uptake protein 2"
FT /id="PRO_0000195044"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 75
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 143 AA; 16069 MW; F3AC3A5302909139 CRC64;
MPMHFIFSDE AVLLFDFWRV HSPTGMALSV LVVLLLAVLY EGIKVGKAKL LHKTLESLPA
TNSQQFILGP DQDSTGSRST SDNRTRLRWF LCYFGQSLVH VIQVVIGYFV MLAVMSYNTW
IFLGVVLGSA VGYYLAYPLL NMT
