ID   COPT2_ORYSJ             Reviewed;         151 AA.
AC   Q60EN8;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Copper transporter 2;
DE            Short=OsCOPT2;
GN   Name=COPT2; OrderedLocusNames=Os05g0424700, LOC_Os05g35050;
GN   ORFNames=OJ1212_B02.11;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA   Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA   Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA   Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT   "A fine physical map of the rice chromosome 5.";
RL   Mol. Genet. Genomics 274:337-345(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   FUNCTION, INTERACTION WITH SWEET11 AND COPT1, SUBCELLULAR LOCATION, AND
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Mudanjiang 8, and cv. Zhonghua 11;
RX   PubMed=20852017; DOI=10.1105/tpc.110.078022;
RA   Antony G., Zhou J., Huang S., Li T., Liu B., White F., Yang B., Yuan M.,
RA   Chu Z., Li X., Xu C., Wang S.;
RT   "Rice xa13 recessive resistance to bacterial blight is defeated by
RT   induction of the disease susceptibility gene Os-11N3. The bacterial
RT   pathogen Xanthomonas oryzae overcomes rice defenses by regulating host
RT   copper redistribution.";
RL   Plant Cell 22:3164-3176(2010).
CC   -!- FUNCTION: Involved in the transport of copper, in cooperation with
CC       SWEET11 and COPT1. Contributes to the removal of copper (Cu) from
CC       xylem, and thus to the sensitivity toward bacterial pathogens such as
CC       X.oryzae pv. oryzae (Xoo). {ECO:0000269|PubMed:20852017}.
CC   -!- SUBUNIT: Self-interacts. Interacts with SWEET11 and COPT1.
CC       {ECO:0000269|PubMed:20852017}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20852017};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:20852017}.
CC   -!- DISRUPTION PHENOTYPE: Reduced copper transport ability, increase in
CC       copper content of the xylem, and enhanced resistance against X.oryzae
CC       pv. oryzae (Xoo) PXO99. {ECO:0000269|PubMed:20852017}.
CC   -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC       SLC31A subfamily. {ECO:0000305}.
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DR   EMBL; AC109595; AAV24776.1; -; Genomic_DNA.
DR   EMBL; AP008211; BAF17508.1; -; Genomic_DNA.
DR   EMBL; AP014961; BAS94104.1; -; Genomic_DNA.
DR   EMBL; AK107848; BAG98176.1; -; mRNA.
DR   RefSeq; XP_015638992.1; XM_015783506.1.
DR   AlphaFoldDB; Q60EN8; -.
DR   SMR; Q60EN8; -.
DR   STRING; 4530.OS05T0424700-01; -.
DR   PaxDb; Q60EN8; -.
DR   PRIDE; Q60EN8; -.
DR   EnsemblPlants; Os05t0424700-01; Os05t0424700-01; Os05g0424700.
DR   GeneID; 4338846; -.
DR   Gramene; Os05t0424700-01; Os05t0424700-01; Os05g0424700.
DR   KEGG; osa:4338846; -.
DR   eggNOG; KOG3386; Eukaryota.
DR   HOGENOM; CLU_079690_1_0_1; -.
DR   InParanoid; Q60EN8; -.
DR   OMA; VEWISHT; -.
DR   OrthoDB; 1389393at2759; -.
DR   Proteomes; UP000000763; Chromosome 5.
DR   Proteomes; UP000059680; Chromosome 5.
DR   ExpressionAtlas; Q60EN8; baseline and differential.
DR   Genevisible; Q60EN8; OS.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0005375; F:copper ion transmembrane transporter activity; IMP:UniProtKB.
DR   GO; GO:0043621; F:protein self-association; IDA:UniProtKB.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR   GO; GO:0006825; P:copper ion transport; IMP:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR007274; Cop_transporter.
DR   PANTHER; PTHR12483; PTHR12483; 1.
DR   Pfam; PF04145; Ctr; 2.
PE   1: Evidence at protein level;
KW   Cell membrane; Copper; Copper transport; Ion transport; Membrane;
KW   Plant defense; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..151
FT                   /note="Copper transporter 2"
FT                   /id="PRO_0000399999"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   151 AA;  16269 MW;  C2D355A7BADAE20B CRC64;
     MDMGGNGMAM PPPPAPVKKA RYMHMTFFWG KNTEVLFTLW PGARGGMYAL AILFMFALAV
     LLEFRGYRVL EARLARRRAP RAAAALRTAV HAVRVGVAYL IMLALMSFNG GVFLAIVAGH
     AAGFLAFRAG LCGGGPAPPL EEDRKNDPVC C