ID   COPT3_ARATH             Reviewed;         151 AA.
AC   Q9FGU8; Q8LB92; Q8SAA6;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Copper transporter 3;
DE            Short=AtCOPT3;
GN   Name=COPT3; OrderedLocusNames=At5g59040; ORFNames=K18B18.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 20-151, FUNCTION, TISSUE SPECIFICITY,
RP   INDUCTION, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12650623; DOI=10.1023/a:1022345507112;
RA   Sancenon V., Puig S., Mira H., Thiele D.J., Penarrubia L.;
RT   "Identification of a copper transporter family in Arabidopsis thaliana.";
RL   Plant Mol. Biol. 51:577-587(2003).
CC   -!- FUNCTION: Involved in the transport of copper.
CC       {ECO:0000269|PubMed:12650623}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in stems and at lower levels in
CC       leaves and flowers. {ECO:0000269|PubMed:12650623}.
CC   -!- INDUCTION: No change in expression levels after treatment with high
CC       concentrations of copper. {ECO:0000269|PubMed:12650623}.
CC   -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC       SLC31A subfamily. {ECO:0000305}.
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DR   EMBL; AB024027; BAB10780.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97133.1; -; Genomic_DNA.
DR   EMBL; DQ447093; ABE66262.1; -; mRNA.
DR   EMBL; AY087351; AAM64901.1; -; mRNA.
DR   EMBL; AF466371; AAL74263.1; -; mRNA.
DR   RefSeq; NP_200712.1; NM_125294.3.
DR   AlphaFoldDB; Q9FGU8; -.
DR   SMR; Q9FGU8; -.
DR   STRING; 3702.AT5G59040.1; -.
DR   PaxDb; Q9FGU8; -.
DR   PRIDE; Q9FGU8; -.
DR   ProteomicsDB; 241171; -.
DR   EnsemblPlants; AT5G59040.1; AT5G59040.1; AT5G59040.
DR   GeneID; 836021; -.
DR   Gramene; AT5G59040.1; AT5G59040.1; AT5G59040.
DR   KEGG; ath:AT5G59040; -.
DR   Araport; AT5G59040; -.
DR   TAIR; locus:2153311; AT5G59040.
DR   eggNOG; KOG3386; Eukaryota.
DR   HOGENOM; CLU_079690_1_2_1; -.
DR   InParanoid; Q9FGU8; -.
DR   OMA; NSHTEVQ; -.
DR   OrthoDB; 1389393at2759; -.
DR   PhylomeDB; Q9FGU8; -.
DR   PRO; PR:Q9FGU8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FGU8; baseline and differential.
DR   Genevisible; Q9FGU8; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005375; F:copper ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR007274; Cop_transporter.
DR   PANTHER; PTHR12483; PTHR12483; 1.
DR   Pfam; PF04145; Ctr; 1.
PE   2: Evidence at transcript level;
KW   Copper; Copper transport; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..151
FT                   /note="Copper transporter 3"
FT                   /id="PRO_0000399994"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        37..39
FT                   /note="GKT -> VKN (in Ref. 4; AAM64901)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   151 AA;  16170 MW;  6F82F2E10A783384 CRC64;
     MNGMSGSSPA APAPSPSSFF QHRHRHGGMM HMTFFWGKTT EVLFDGWPGT SLKMYWVCLA
     VIFVISAFSE CLSRCGFMKS GPASLGGGLL QTAVYTVRAA LSYLVMLAVM SFNGGVFVAA
     MAGFGLGFMI FGSRAFRATS SNSHTEVQSH C