ID   COPT4_ARATH             Reviewed;         145 AA.
AC   Q8SAA5;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Copper transporter 4;
DE            Short=AtCOPT4;
GN   Name=COPT4; OrderedLocusNames=At2g37925; ORFNames=T8P21.17;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP   NOMENCLATURE.
RX   PubMed=12650623; DOI=10.1023/a:1022345507112;
RA   Sancenon V., Puig S., Mira H., Thiele D.J., Penarrubia L.;
RT   "Identification of a copper transporter family in Arabidopsis thaliana.";
RL   Plant Mol. Biol. 51:577-587(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   INDUCTION.
RX   PubMed=20117084; DOI=10.1016/j.bbrc.2010.01.111;
RA   del Pozo T., Cambiazo V., Gonzalez M.;
RT   "Gene expression profiling analysis of copper homeostasis in Arabidopsis
RT   thaliana.";
RL   Biochem. Biophys. Res. Commun. 393:248-252(2010).
CC   -!- FUNCTION: Involved in the transport of copper. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in roots and at lower levels in
CC       leaves, stems and flowers. {ECO:0000269|PubMed:12650623}.
CC   -!- INDUCTION: Down-regulated by treatment with high concentrations of
CC       copper. {ECO:0000269|PubMed:20117084}.
CC   -!- SIMILARITY: Belongs to the copper transporter (Ctr) (TC 1.A.56) family.
CC       SLC31A subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF466372; AAL74264.1; -; mRNA.
DR   EMBL; CP002685; AEC09466.1; -; Genomic_DNA.
DR   RefSeq; NP_850289.1; NM_179958.2.
DR   AlphaFoldDB; Q8SAA5; -.
DR   SMR; Q8SAA5; -.
DR   STRING; 3702.AT2G37925.1; -.
DR   PaxDb; Q8SAA5; -.
DR   PRIDE; Q8SAA5; -.
DR   EnsemblPlants; AT2G37925.1; AT2G37925.1; AT2G37925.
DR   GeneID; 818369; -.
DR   Gramene; AT2G37925.1; AT2G37925.1; AT2G37925.
DR   KEGG; ath:AT2G37925; -.
DR   Araport; AT2G37925; -.
DR   TAIR; locus:504955905; AT2G37925.
DR   eggNOG; KOG3386; Eukaryota.
DR   HOGENOM; CLU_079690_1_2_1; -.
DR   InParanoid; Q8SAA5; -.
DR   OMA; HAGDITH; -.
DR   OrthoDB; 1389393at2759; -.
DR   PhylomeDB; Q8SAA5; -.
DR   PRO; PR:Q8SAA5; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q8SAA5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005375; F:copper ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR007274; Cop_transporter.
DR   PANTHER; PTHR12483; PTHR12483; 1.
DR   Pfam; PF04145; Ctr; 2.
PE   2: Evidence at transcript level;
KW   Copper; Copper transport; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..145
FT                   /note="Copper transporter 4"
FT                   /id="PRO_0000399995"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        111
FT                   /note="A -> T (in Ref. 1; AAL74264)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   145 AA;  16103 MW;  3F52DDE00BEC734E CRC64;
     MLSSKNVVVV EAWNTTTTTQ TQTPHRPSLL HPTFYWGYNC QVLFSGWPGS DRGMYALALI
     FVFFLAFLAE WLARCSDASS IKQGADKLAK VAFRTAMYTV KSGFSYLVIL AVVSFNGGVF
     LAAIFGHALG FAVFRGRAFR NRDIQ