ID   COPZB_DICDI             Reviewed;         178 AA.
AC   Q54CA7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Probable coatomer subunit zeta-B;
DE   AltName: Full=Zeta-B-coat protein;
DE            Short=Zeta-B COP;
GN   Name=copZb; ORFNames=DDB_G0293086;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC       dilysine motifs and reversibly associates with Golgi non-clathrin-
CC       coated vesicles, which further mediate biosynthetic protein transport
CC       from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC       complex is required for budding from Golgi membranes, and is essential
CC       for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC       (By similarity). The zeta subunit may be involved in regulating the
CC       coat assembly and, hence, the rate of biosynthetic protein transport
CC       due to its association-dissociation properties with the coatomer
CC       complex (By similarity). {ECO:0000250|UniProtKB:P53600}.
CC   -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC       beta', gamma, delta, epsilon and zeta subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000199; EAL60895.1; -; Genomic_DNA.
DR   RefSeq; XP_629312.1; XM_629310.1.
DR   AlphaFoldDB; Q54CA7; -.
DR   SMR; Q54CA7; -.
DR   STRING; 44689.DDB0305237; -.
DR   PaxDb; Q54CA7; -.
DR   EnsemblProtists; EAL60895; EAL60895; DDB_G0293086.
DR   GeneID; 8629035; -.
DR   KEGG; ddi:DDB_G0293086; -.
DR   dictyBase; DDB_G0293086; copZb.
DR   eggNOG; KOG3343; Eukaryota.
DR   HOGENOM; CLU_086803_0_0_1; -.
DR   InParanoid; Q54CA7; -.
DR   OMA; NEQTIMS; -.
DR   PhylomeDB; Q54CA7; -.
DR   Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-DDI-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:Q54CA7; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0030126; C:COPI vesicle coat; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR039652; Coatomer_zeta.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11043; PTHR11043; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..178
FT                   /note="Probable coatomer subunit zeta-B"
FT                   /id="PRO_0000328106"
SQ   SEQUENCE   178 AA;  19954 MW;  FCF98C03D0AC325A CRC64;
     MDETVYQIKA IIVLDNNGKR LCSCFYDPPG TPITPLTEKD KFEKLIFEKC KTSNCELEII
     DNKVVIGSKQ SDVWIFVVGN SLNSNELALL DVLNTLISLF KKACATDESI MITKKTFLEN
     YALIRLYIDE IVSDGIIFEV DEETILNRVP IADNAAQSLN EAIEMAKEKA KGFGFGFL