ID   COPZ_ENCCU              Reviewed;         165 AA.
AC   Q8SRD1;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Coatomer subunit zeta;
DE   AltName: Full=Zeta-coat protein;
DE            Short=Zeta-COP;
GN   OrderedLocusNames=ECU08_0680;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC       dilysine motifs and reversibly associates with Golgi non-clathrin-
CC       coated vesicles, which further mediate biosynthetic protein transport
CC       from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC       complex is required for budding from Golgi membranes, and is essential
CC       for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
CC       (By similarity). The zeta subunit may be involved in regulating the
CC       coat assembly and, hence, the rate of biosynthetic protein transport
CC       due to its association-dissociation properties with the coatomer
CC       complex (By similarity). {ECO:0000250|UniProtKB:P53600}.
CC   -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC       beta', gamma, delta, epsilon and zeta subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on
CC       the cytoplasmic side of the Golgi, as well as on the vesicles/buds
CC       originating from it. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AL590448; CAD26373.1; -; Genomic_DNA.
DR   RefSeq; NP_597197.1; NM_001041806.1.
DR   AlphaFoldDB; Q8SRD1; -.
DR   SMR; Q8SRD1; -.
DR   GeneID; 859619; -.
DR   KEGG; ecu:ECU08_0680; -.
DR   VEuPathDB; MicrosporidiaDB:ECU08_0680; -.
DR   HOGENOM; CLU_129942_0_0_1; -.
DR   InParanoid; Q8SRD1; -.
DR   OMA; MIVENKS; -.
DR   OrthoDB; 1440990at2759; -.
DR   Proteomes; UP000000819; Chromosome VIII.
DR   GO; GO:0030663; C:COPI-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..165
FT                   /note="Coatomer subunit zeta"
FT                   /id="PRO_0000383108"
SQ   SEQUENCE   165 AA;  18742 MW;  7CDAB6C35BC11A6C CRC64;
     MNLFDIEGLL VADSQGEILY RRVFSKEEEI AAKIAEKAAG DRESISMFYD RIVMCKRLDE
     VLLIIYSPMD VNEPFVGQVF DEFTAAFIGI VKTPTRERVW KKYDQIVLLV AEFLYEGIVM
     SGKSDEMLDK LPKRNFEGVD GMKVPRGFAS FLHKATKSLS IGSNK