COQ10_DROME
ID COQ10_DROME Reviewed; 242 AA.
AC Q8MLL3; Q29R00; Q6NN87; Q7KRP4; Q9V9C2;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Coenzyme Q-binding protein COQ10, mitochondrial;
DE Flags: Precursor;
GN Name=Coq10; ORFNames=CG9410;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley; TISSUE=Testis;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the function of coenzyme Q in the respiratory
CC chain. May serve as a chaperone or may be involved in the transport of
CC Q6 from its site of synthesis to the catalytic sites of the respiratory
CC complexes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with coenzyme Q. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B; Synonyms=D;
CC IsoId=Q8MLL3-1; Sequence=Displayed;
CC Name=A;
CC IsoId=Q8MLL3-2; Sequence=VSP_017688;
CC -!- SIMILARITY: Belongs to the COQ10 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57372.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68384.1; -; Genomic_DNA.
DR EMBL; AE013599; AAS64779.2; -; Genomic_DNA.
DR EMBL; BT011406; AAR96198.1; -; mRNA.
DR EMBL; BT024240; ABC86302.1; -; mRNA.
DR RefSeq; NP_610221.1; NM_136377.5. [Q8MLL3-2]
DR RefSeq; NP_724484.1; NM_165481.5. [Q8MLL3-1]
DR AlphaFoldDB; Q8MLL3; -.
DR SMR; Q8MLL3; -.
DR BioGRID; 61466; 1.
DR STRING; 7227.FBpp0085450; -.
DR PaxDb; Q8MLL3; -.
DR DNASU; 35568; -.
DR EnsemblMetazoa; FBtr0086115; FBpp0085449; FBgn0033086. [Q8MLL3-2]
DR EnsemblMetazoa; FBtr0086116; FBpp0085450; FBgn0033086. [Q8MLL3-1]
DR GeneID; 35568; -.
DR KEGG; dme:Dmel_CG9410; -.
DR UCSC; CG9410-RA; d. melanogaster. [Q8MLL3-1]
DR FlyBase; FBgn0033086; CG9410.
DR VEuPathDB; VectorBase:FBgn0033086; -.
DR eggNOG; KOG3177; Eukaryota.
DR GeneTree; ENSGT00940000173806; -.
DR InParanoid; Q8MLL3; -.
DR OMA; HEFIPYC; -.
DR PhylomeDB; Q8MLL3; -.
DR Reactome; R-DME-611105; Respiratory electron transport.
DR BioGRID-ORCS; 35568; 1 hit in 3 CRISPR screens.
DR GenomeRNAi; 35568; -.
DR PRO; PR:Q8MLL3; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033086; Expressed in testis and 47 other tissues.
DR ExpressionAtlas; Q8MLL3; baseline and differential.
DR Genevisible; Q8MLL3; DM.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0048039; F:ubiquinone binding; IBA:GO_Central.
DR GO; GO:0045333; P:cellular respiration; IBA:GO_Central.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IBA:GO_Central.
DR CDD; cd07813; COQ10p_like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR044996; COQ10-like.
DR InterPro; IPR005031; COQ10_START.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR12901; PTHR12901; 1.
DR Pfam; PF03364; Polyketide_cyc; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..242
FT /note="Coenzyme Q-binding protein COQ10, mitochondrial"
FT /id="PRO_0000228653"
FT VAR_SEQ 22..56
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000305"
FT /id="VSP_017688"
FT CONFLICT 17..19
FT /note="PLI -> LVP (in Ref. 3; AAR96198)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="D -> E (in Ref. 3; AAR96198)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 242 AA; 27632 MW; 9BB960B8019B295E CRC64;
MLKGSTLKAL DVRILWPLIE TRSAGKCKLH NPRPTPNRNI AAAKLIVTLR LLLSCCSGGH
QRSFSSSTHR SYITFNDFRK KHRWYTKKEL VGYSMQDMYS VVSDVSNYHK FVPYVKRSDV
HSRGSEGFKA DLIVGFPPLN EAYTSQVTLV PPSLVKSECH DGRLFNYLLN EWSFKPGLKD
IPNSCVLDFK VSFEFKSLLH SNVANIFFDL ICDQMENAFI QEVRRRSGPP SIRSHVLTSD
RS
