COQ10_YEAST
ID COQ10_YEAST Reviewed; 207 AA.
AC Q08058; D6W259;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Coenzyme Q-binding protein COQ10, mitochondrial;
DE Flags: Precursor;
GN Name=COQ10; OrderedLocusNames=YOL008W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH COENZYME Q.
RX PubMed=16230336; DOI=10.1074/jbc.m510768200;
RA Barros M.H., Johnson A., Gin P., Marbois B.N., Clarke C.F., Tzagoloff A.;
RT "The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein
RT required for function of coenzyme Q in respiration.";
RL J. Biol. Chem. 280:42627-42635(2005).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16823961; DOI=10.1021/pr050477f;
RA Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT "Toward the complete yeast mitochondrial proteome: multidimensional
RT separation techniques for mitochondrial proteomics.";
RL J. Proteome Res. 5:1543-1554(2006).
CC -!- FUNCTION: Required for the function of coenzyme Q in the respiratory
CC chain. May serve as a chaperone or may be involved in the transport of
CC Q6 from its site of synthesis to the catalytic sites of the respiratory
CC complexes. {ECO:0000269|PubMed:16230336}.
CC -!- SUBUNIT: Interacts with coenzyme Q. {ECO:0000269|PubMed:16230336}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:16230336, ECO:0000269|PubMed:16823961}; Peripheral
CC membrane protein {ECO:0000269|PubMed:16230336,
CC ECO:0000269|PubMed:16823961}; Matrix side {ECO:0000269|PubMed:16230336,
CC ECO:0000269|PubMed:16823961}.
CC -!- SIMILARITY: Belongs to the COQ10 family. {ECO:0000305}.
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DR EMBL; Z74750; CAA99007.1; -; Genomic_DNA.
DR EMBL; AY558008; AAS56334.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10775.1; -; Genomic_DNA.
DR PIR; S66690; S66690.
DR RefSeq; NP_014635.1; NM_001183262.1.
DR AlphaFoldDB; Q08058; -.
DR SMR; Q08058; -.
DR BioGRID; 34396; 224.
DR DIP; DIP-4689N; -.
DR MINT; Q08058; -.
DR STRING; 4932.YOL008W; -.
DR MaxQB; Q08058; -.
DR PaxDb; Q08058; -.
DR PRIDE; Q08058; -.
DR DNASU; 854154; -.
DR EnsemblFungi; YOL008W_mRNA; YOL008W; YOL008W.
DR GeneID; 854154; -.
DR KEGG; sce:YOL008W; -.
DR SGD; S000005368; COQ10.
DR VEuPathDB; FungiDB:YOL008W; -.
DR eggNOG; KOG3177; Eukaryota.
DR GeneTree; ENSGT00940000173806; -.
DR HOGENOM; CLU_079653_1_2_1; -.
DR InParanoid; Q08058; -.
DR OMA; HEFIPYC; -.
DR BioCyc; YEAST:G3O-33425-MON; -.
DR PRO; PR:Q08058; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08058; protein.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0048039; F:ubiquinone binding; IDA:SGD.
DR GO; GO:0045333; P:cellular respiration; IMP:SGD.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IMP:SGD.
DR CDD; cd07813; COQ10p_like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR044996; COQ10-like.
DR InterPro; IPR005031; COQ10_START.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR12901; PTHR12901; 1.
DR Pfam; PF03364; Polyketide_cyc; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..39
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 40..207
FT /note="Coenzyme Q-binding protein COQ10, mitochondrial"
FT /id="PRO_0000227688"
SQ SEQUENCE 207 AA; 23765 MW; 8A9F5D48159CC519 CRC64;
MVLIIRPSQT LILFRKAMLK PIGRYPLKRN FFGLSGTNHT IREQRYVLRK AINAPPSTVY
AAVSEVAQYK EFIPYCVDSF VDKRNPVDNK PLIAGLRVGF KQYDEEFICN VTCKDTDHTY
TVVAETISHN LFHLLISKWT IMPHPNRPNA AMVELLLRFK FKSRIYNSVS LIFAKTVTEL
VMNAFAKRAY HLVRLAMLKP SSKEGSP
