COQ11_YEAST
ID COQ11_YEAST Reviewed; 277 AA.
AC Q05892; D6VYT6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=MIOREX complex component 2 {ECO:0000305|PubMed:25683707};
DE AltName: Full=Mitochondrial organization of gene expression protein 2 {ECO:0000303|PubMed:25683707};
GN Name=COQ11 {ECO:0000303|PubMed:25631044};
GN Synonyms=MRX2 {ECO:0000303|PubMed:25683707};
GN OrderedLocusNames=YLR290C {ECO:0000312|SGD:S000004281};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16823961; DOI=10.1021/pr050477f;
RA Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT "Toward the complete yeast mitochondrial proteome: multidimensional
RT separation techniques for mitochondrial proteomics.";
RL J. Proteome Res. 5:1543-1554(2006).
RN [6]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25683707; DOI=10.1016/j.celrep.2015.01.012;
RA Kehrein K., Schilling R., Moller-Hergt B.V., Wurm C.A., Jakobs S.,
RA Lamkemeyer T., Langer T., Ott M.;
RT "Organization of mitochondrial gene expression in two distinct ribosome-
RT containing assemblies.";
RL Cell Rep. 10:843-853(2015).
RN [7]
RP FUNCTION, SUBUNIT, AND DISRUPTION PHENOTYPE.
RX PubMed=25631044; DOI=10.1074/jbc.m114.633131;
RA Allan C.M., Awad A.M., Johnson J.S., Shirasaki D.I., Wang C.,
RA Blaby-Haas C.E., Merchant S.S., Loo J.A., Clarke C.F.;
RT "Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-
RT synthome in Saccharomyces cerevisiae.";
RL J. Biol. Chem. 290:7517-7534(2015).
CC -!- FUNCTION: Component of MIOREX complexes, large expressome-like
CC assemblies of ribosomes with factors involved in all the steps of post-
CC transcriptional gene expression (PubMed:25683707). Component of a
CC multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis
CC (PubMed:25631044). {ECO:0000269|PubMed:25631044,
CC ECO:0000269|PubMed:25683707}.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000305|PubMed:25631044}.
CC -!- SUBUNIT: Associates with the mitochondrial ribosome (PubMed:25683707).
CC Component of a multi-subunit COQ enzyme complex (PubMed:25631044).
CC {ECO:0000269|PubMed:25631044, ECO:0000269|PubMed:25683707}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:16823961}.
CC -!- DISRUPTION PHENOTYPE: Shows impaired de novo coenzyme Q biosynthesis.
CC {ECO:0000269|PubMed:25631044}.
CC -!- MISCELLANEOUS: Present with 1470 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U17243; AAB67336.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09602.1; -; Genomic_DNA.
DR PIR; S50375; S50375.
DR RefSeq; NP_013393.1; NM_001182178.1.
DR AlphaFoldDB; Q05892; -.
DR SMR; Q05892; -.
DR BioGRID; 31556; 210.
DR DIP; DIP-4742N; -.
DR IntAct; Q05892; 1.
DR MINT; Q05892; -.
DR STRING; 4932.YLR290C; -.
DR MaxQB; Q05892; -.
DR PaxDb; Q05892; -.
DR PRIDE; Q05892; -.
DR EnsemblFungi; YLR290C_mRNA; YLR290C; YLR290C.
DR GeneID; 850997; -.
DR KEGG; sce:YLR290C; -.
DR SGD; S000004281; COQ11.
DR VEuPathDB; FungiDB:YLR290C; -.
DR eggNOG; KOG4288; Eukaryota.
DR GeneTree; ENSGT00390000006865; -.
DR HOGENOM; CLU_055314_1_0_1; -.
DR InParanoid; Q05892; -.
DR OMA; VSWERAD; -.
DR BioCyc; YEAST:G3O-32385-MON; -.
DR UniPathway; UPA00232; -.
DR ChiTaRS; COQ11; yeast.
DR PRO; PR:Q05892; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q05892; protein.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR GO; GO:1901006; P:ubiquinone-6 biosynthetic process; IMP:SGD.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ubiquinone biosynthesis.
FT CHAIN 1..277
FT /note="MIOREX complex component 2"
FT /id="PRO_0000268626"
SQ SEQUENCE 277 AA; 31524 MW; 1C7970D1DCAD1049 CRC64;
MIPKLIVFGG NGFLGKRICQ EAVTSGYQVV SVSRSGKAPH SNELNDKQWM QEVQWTAADI
FKPDSYHELL NNATNVVHSL GILLENENYK QTLSKSPTYD SKSRLLSFGA GPNPLKKSSP
YFTYEMMNKQ SAIILADTFK QKILKKSKKE QEKANQRSFT YISADKGFPL IPSGYINSKR
EAEIELEKMQ RYFRPIIVRP GFMFDEHRNA IGPRSFIHTA LELLYCGNKF LLRNKLQLLN
DLIRPTVSTQ QVSKSVLKNI ENPDFKGVVT LEEILKA
