ID   2ABG_RAT                Reviewed;         447 AA.
AC   P97888;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform;
DE   AltName: Full=PP2A subunit B isoform B55-gamma;
DE   AltName: Full=PP2A subunit B isoform BRgamma;
DE   AltName: Full=PP2A subunit B isoform PR55-gamma;
DE   AltName: Full=PP2A subunit B isoform R2-gamma;
DE   AltName: Full=PP2A subunit B isoform gamma;
GN   Name=Ppp2r2c;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=7607250; DOI=10.1111/j.1432-1033.1995.tb20619.x;
RA   Akiyama N., Shima H., Hatano Y., Osawa Y., Sugimura T., Nagao M.;
RT   "cDNA cloning of BR gamma, a novel brain-specific isoform of the B
RT   regulatory subunit of type-2A protein phosphatase.";
RL   Eur. J. Biochem. 230:766-772(1995).
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules (By
CC       similarity). Interacts with IER5 (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:Q9Y2T4}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; D38261; BAA07413.1; -; mRNA.
DR   RefSeq; NP_476457.1; NM_057116.1.
DR   AlphaFoldDB; P97888; -.
DR   SMR; P97888; -.
DR   STRING; 10116.ENSRNOP00000007293; -.
DR   jPOST; P97888; -.
DR   PRIDE; P97888; -.
DR   GeneID; 117256; -.
DR   KEGG; rno:117256; -.
DR   CTD; 5522; -.
DR   RGD; 620920; Ppp2r2c.
DR   eggNOG; KOG1354; Eukaryota.
DR   InParanoid; P97888; -.
DR   OrthoDB; 810409at2759; -.
DR   PhylomeDB; P97888; -.
DR   PRO; PR:P97888; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IBA:GO_Central.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..447
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B gamma isoform"
FT                   /id="PRO_0000071432"
FT   REPEAT          22..61
FT                   /note="WD 1"
FT   REPEAT          87..128
FT                   /note="WD 2"
FT   REPEAT          171..209
FT                   /note="WD 3"
FT   REPEAT          220..260
FT                   /note="WD 4"
FT   REPEAT          279..317
FT                   /note="WD 5"
FT   REPEAT          334..375
FT                   /note="WD 6"
FT   REPEAT          410..446
FT                   /note="WD 7"
SQ   SEQUENCE   447 AA;  51474 MW;  DE16E4EFC775F3C5 CRC64;
     MGEDTDTRKI NHSFLRDHSY VTEADVISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA
     PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI
     TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS
     VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY
     SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
     YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYESDCIFD KFECAWNGSD SVIMTGAYNN
     FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW
     HPAENIIAIA ATNNLYIFQD KVNSDMH