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COQ41_CAEBR
ID   COQ41_CAEBR             Reviewed;         227 AA.
AC   C0HL93; A8XEQ6; A8XEQ7;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   18-JUL-2018, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Ubiquinone biosynthesis protein coq-4.1, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4.1 {ECO:0000255|HAMAP-Rule:MF_03111};
GN   Name=coq-4.1 {ECO:0000255|HAMAP-Rule:MF_03111};
GN   ORFNames=CBG11976 {ECO:0000312|WormBase:CBG11976};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- CAUTION: The coq-4 gene is duplicated in C.briggsae to produce coq-4.1
CC       and coq-4.2. coq-4.1 encodes a longer functional protein while coq-4.2
CC       is shorter and may be non-functional or have acquired a different
CC       function to coq-4.1. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP31025.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; HE601540; CAP31025.2; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; C0HL93; -.
DR   SMR; C0HL93; -.
DR   STRING; 6238.CBG11976; -.
DR   EnsemblMetazoa; CBG11976.1; CBG11976.1; WBGene00032993.
DR   WormBase; CBG11976; CBP41124; WBGene00032993; Cbr-coq-4.1.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..227
FT                   /note="Ubiquinone biosynthesis protein coq-4.1,
FT                   mitochondrial"
FT                   /id="PRO_0000444676"
SQ   SEQUENCE   227 AA;  25833 MW;  647DBD1F35D32EE7 CRC64;
     MSAQKLYGSH VPLAPLSRIL LGIGSAATAI TDPRRGDMVA AMGETTAVGP VLENIRRRME
     SDKIGKKLLM EKPRISNETI DRKWLAQLPD GTLGKHYSNF LERLNTSPDA RPTVKYIDNL
     EHLYVMQRYR ETHDFTHIAL EQKTNMLGEV TVKYFEGIQY GLPMCVSGIF GGARLLTKNR
     SEFLHKNLPW VVEQAKTARF FMAFDWENHF ESQLSDVQKE LNVVPLI
 
 
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