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COQ41_CULQU
ID   COQ41_CULQU             Reviewed;         268 AA.
AC   B0WH96;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog 1, mitochondrial;
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog 1 {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   ORFNames=CPIJ006564;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; DS231933; EDS27554.1; -; Genomic_DNA.
DR   RefSeq; XP_001848061.1; XM_001848009.1.
DR   AlphaFoldDB; B0WH96; -.
DR   SMR; B0WH96; -.
DR   STRING; 7176.CPIJ006564-PA; -.
DR   KEGG; cqu:CpipJ_CPIJ006564; -.
DR   VEuPathDB; VectorBase:CPIJ006564; -.
DR   VEuPathDB; VectorBase:CQUJHB006863; -.
DR   eggNOG; KOG3244; Eukaryota.
DR   HOGENOM; CLU_061241_1_1_1; -.
DR   InParanoid; B0WH96; -.
DR   OMA; KFFEFAN; -.
DR   OrthoDB; 1264469at2759; -.
DR   PhylomeDB; B0WH96; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Ubiquinone biosynthesis.
FT   TRANSIT         1..18
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           19..268
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog 1,
FT                   mitochondrial"
FT                   /id="PRO_0000388059"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  30569 MW;  5C76CA810007E4C0 CRC64;
     MFLRRVHPVR LGHASQRSLT TTKSRNESTT TTVEAPQAAP SPPPDAFTEE FLRNQIKVTE
     LQRVILGVGS SLAALVNPRR HDMIACLGET TGVPALDAIR RQMLASDEGR QILADRPRIN
     TRTVDMAALK ALPETSFGHQ YVHFLEKHDI TPDSRAEVRF MDDPELAYVM TRYREVHDLV
     HTVLGMPTNM LGEVAVKWVE ALNTGLPMCY GGAVFGAQRQ NYLRHYLPWA LRMGRQVRPL
     MNVYWEKRWE QDMAELRQEL NIEELVIN
 
 
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