COQ41_CULQU
ID COQ41_CULQU Reviewed; 268 AA.
AC B0WH96;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog 1, mitochondrial;
DE AltName: Full=Coenzyme Q biosynthesis protein 4 homolog 1 {ECO:0000255|HAMAP-Rule:MF_03111};
DE Flags: Precursor;
GN ORFNames=CPIJ006564;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC role in organizing a multi-subunit COQ enzyme complex required for
CC coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
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DR EMBL; DS231933; EDS27554.1; -; Genomic_DNA.
DR RefSeq; XP_001848061.1; XM_001848009.1.
DR AlphaFoldDB; B0WH96; -.
DR SMR; B0WH96; -.
DR STRING; 7176.CPIJ006564-PA; -.
DR KEGG; cqu:CpipJ_CPIJ006564; -.
DR VEuPathDB; VectorBase:CPIJ006564; -.
DR VEuPathDB; VectorBase:CQUJHB006863; -.
DR eggNOG; KOG3244; Eukaryota.
DR HOGENOM; CLU_061241_1_1_1; -.
DR InParanoid; B0WH96; -.
DR OMA; KFFEFAN; -.
DR OrthoDB; 1264469at2759; -.
DR PhylomeDB; B0WH96; -.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03111; Coq4; 1.
DR InterPro; IPR007715; Coq4.
DR InterPro; IPR027540; Coq4_euk.
DR PANTHER; PTHR12922; PTHR12922; 1.
DR Pfam; PF05019; Coq4; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Ubiquinone biosynthesis.
FT TRANSIT 1..18
FT /note="Mitochondrion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT CHAIN 19..268
FT /note="Ubiquinone biosynthesis protein COQ4 homolog 1,
FT mitochondrial"
FT /id="PRO_0000388059"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 268 AA; 30569 MW; 5C76CA810007E4C0 CRC64;
MFLRRVHPVR LGHASQRSLT TTKSRNESTT TTVEAPQAAP SPPPDAFTEE FLRNQIKVTE
LQRVILGVGS SLAALVNPRR HDMIACLGET TGVPALDAIR RQMLASDEGR QILADRPRIN
TRTVDMAALK ALPETSFGHQ YVHFLEKHDI TPDSRAEVRF MDDPELAYVM TRYREVHDLV
HTVLGMPTNM LGEVAVKWVE ALNTGLPMCY GGAVFGAQRQ NYLRHYLPWA LRMGRQVRPL
MNVYWEKRWE QDMAELRQEL NIEELVIN