ID   COQ42_CULQU             Reviewed;         223 AA.
AC   B0XLA4;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog 2, mitochondrial;
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog 2 {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   ORFNames=CPIJ019881;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; DS234376; EDS33774.1; -; Genomic_DNA.
DR   RefSeq; XP_001870426.1; XM_001870391.1.
DR   AlphaFoldDB; B0XLA4; -.
DR   SMR; B0XLA4; -.
DR   STRING; 7176.CPIJ019881-PA; -.
DR   GeneID; 6054526; -.
DR   KEGG; cqu:CpipJ_CPIJ019881; -.
DR   VEuPathDB; VectorBase:CPIJ019881; -.
DR   VEuPathDB; VectorBase:CQUJHB006863; -.
DR   eggNOG; KOG3244; Eukaryota.
DR   HOGENOM; CLU_061241_1_1_1; -.
DR   InParanoid; B0XLA4; -.
DR   OMA; VEHYAKH; -.
DR   OrthoDB; 1264469at2759; -.
DR   PhylomeDB; B0XLA4; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Ubiquinone biosynthesis.
FT   TRANSIT         1..26
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           27..223
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog 2,
FT                   mitochondrial"
FT                   /id="PRO_0000388060"
FT   REGION          21..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   223 AA;  24925 MW;  9319B479A2466A7E CRC64;
     MFLRRVHPVR LGHAIQRSLT TTKSRNESTT TTVEAPQAVP SPPPDAFTEE FLRNQIKVTE
     LQRVILGVGS SLAALVNPRR HDMIACLGET TGVPALDAIR RQMLASDEGR QILADRPRIN
     TRTVDMAALK ALPETSFGHQ YVHFLEKHDI TPDSRAEVRF MDDPELAYVM TRYREVHDLV
     HTVLGMPTNM LGEVAVKWVE ALNTGLPMCY GGAVFGAFRL RPK