COQ4_ASPFN
ID COQ4_ASPFN Reviewed; 285 AA.
AC B8NV05; B8NV06;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Ubiquinone biosynthesis protein coq4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
DE Flags: Precursor;
GN Name=coq4; ORFNames=AFLA_102990/103000;
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC 167;
RX PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
CC -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC role in organizing a multi-subunit COQ enzyme complex required for
CC coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC at least coq3, coq4, coq5, coq6, coq7 and coq9. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EED46634.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EED46634.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=EED46635.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; EQ963484; EED46634.1; ALT_SEQ; Genomic_DNA.
DR EMBL; EQ963484; EED46635.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_002384170.1; XM_002384129.1.
DR RefSeq; XP_002384171.1; XM_002384130.1.
DR AlphaFoldDB; B8NV05; -.
DR SMR; B8NV05; -.
DR STRING; 5059.CADAFLAP00012035; -.
DR EnsemblFungi; EED46635; EED46635; AFLA_103000.
DR eggNOG; KOG3244; Eukaryota.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03111; Coq4; 1.
DR InterPro; IPR007715; Coq4.
DR InterPro; IPR027540; Coq4_euk.
DR PANTHER; PTHR12922; PTHR12922; 1.
DR Pfam; PF05019; Coq4; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Transit peptide;
KW Ubiquinone biosynthesis.
FT TRANSIT 1..38
FT /note="Mitochondrion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT CHAIN 39..285
FT /note="Ubiquinone biosynthesis protein coq4, mitochondrial"
FT /id="PRO_0000388095"
SQ SEQUENCE 285 AA; 32568 MW; 6975218309C2DAF5 CRC64;
MSVLRRRGAL SLRELSLSTP VTVVSCRARS FSVNNRPPPK YPGHVPLNFV ERGALAVGSA
VGALLNPRRA DLIAACGEAT ATPYFIYRLR DAMLSDPTGR QILRERPRIT SETLPLPYLR
SLPENSVGRT YAAWLDREGV SPDTRDNVQY IDDEECAYVM QRYRECHDFY HAVTGLPTFV
EGEIALKAFE FLNTLIPMTG LSMFAAVRLK PAERERFFAL WLPWAVRSGL ASKELINVYW
EKILEKDVDE LRGELGIEKP PDMREIRRMI REQKKREKER LQQSA
