COQ4_BOTFB
ID COQ4_BOTFB Reviewed; 280 AA.
AC A6SS55;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Ubiquinone biosynthesis protein coq4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
DE Flags: Precursor;
GN Name=coq4; ORFNames=BC1G_15620;
OS Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=332648;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B05.10;
RX PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC role in organizing a multi-subunit COQ enzyme complex required for
CC coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC at least coq3, coq4, coq5, coq6, coq7 and coq9. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
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DR EMBL; CH477028; EDN22708.1; -; Genomic_DNA.
DR RefSeq; XP_001545869.1; XM_001545819.1.
DR AlphaFoldDB; A6SS55; -.
DR SMR; A6SS55; -.
DR PRIDE; A6SS55; -.
DR GeneID; 5426342; -.
DR KEGG; bfu:BCIN_01g01870; -.
DR VEuPathDB; FungiDB:Bcin01g01870; -.
DR OMA; KFFEFAN; -.
DR OrthoDB; 1264469at2759; -.
DR UniPathway; UPA00232; -.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03111; Coq4; 1.
DR InterPro; IPR007715; Coq4.
DR InterPro; IPR027540; Coq4_euk.
DR PANTHER; PTHR12922; PTHR12922; 1.
DR Pfam; PF05019; Coq4; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Transit peptide;
KW Ubiquinone biosynthesis.
FT TRANSIT 1..31
FT /note="Mitochondrion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT CHAIN 32..280
FT /note="Ubiquinone biosynthesis protein coq4, mitochondrial"
FT /id="PRO_0000388101"
SQ SEQUENCE 280 AA; 32015 MW; 58C9142DBA68AED1 CRC64;
MSLSPRLYTQ VSRLPRELLT ACSITLATRS FSVLHRPAPN YPGHVPLTSI ERGGLAVGSA
VMAFFNPYRA DLIAACGEAT ATPYFIYRLR DAMLSSPTGR RILRDRPRIS SKTLSMPRLR
ALPPNTVGRC YAEWLDREGV SPDTRDSVKY IDDEECAYVM QRYRECHDFY HAITGLPIVR
EGEVALKAFE FANTLLPMTG LSMFAVMSLK PAERRRFFTI YAPWAFANGL KAEEVINVYW
EEQLERSVEE LREELGIEKP LDLRDIRRME KERKKAQKAT