ID   COQ4_CAEEL              Reviewed;         231 AA.
AC   P91428;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Ubiquinone biosynthesis protein coq-4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
GN   Name=coq-4 {ECO:0000255|HAMAP-Rule:MF_03111}; ORFNames=T03F1.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=12709403; DOI=10.1096/fj.02-1022fje;
RA   Asencio C., Rodriguez-Aguilera J.C., Ruiz-Ferrer M., Vela J., Navas P.;
RT   "Silencing of ubiquinone biosynthesis genes extends life span in
RT   Caenorhabditis elegans.";
RL   FASEB J. 17:1135-1137(2003).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- DISRUPTION PHENOTYPE: Extends the life span.
CC       {ECO:0000269|PubMed:12709403}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; FO080917; CCD67787.1; -; Genomic_DNA.
DR   PIR; T29199; T29199.
DR   RefSeq; NP_491246.4; NM_058845.4.
DR   AlphaFoldDB; P91428; -.
DR   SMR; P91428; -.
DR   STRING; 6239.T03F1.2; -.
DR   EPD; P91428; -.
DR   PaxDb; P91428; -.
DR   PeptideAtlas; P91428; -.
DR   EnsemblMetazoa; T03F1.2.1; T03F1.2.1; WBGene00000764.
DR   GeneID; 171966; -.
DR   KEGG; cel:CELE_T03F1.2; -.
DR   UCSC; T03F1.2; c. elegans.
DR   CTD; 171966; -.
DR   WormBase; T03F1.2; CE40117; WBGene00000764; coq-4.
DR   eggNOG; KOG3244; Eukaryota.
DR   GeneTree; ENSGT00390000003828; -.
DR   HOGENOM; CLU_061241_1_1_1; -.
DR   InParanoid; P91428; -.
DR   OMA; PWVVEQA; -.
DR   OrthoDB; 1264469at2759; -.
DR   PhylomeDB; P91428; -.
DR   UniPathway; UPA00232; -.
DR   PRO; PR:P91428; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00000764; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; ISS:WormBase.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IMP:WormBase.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..231
FT                   /note="Ubiquinone biosynthesis protein coq-4,
FT                   mitochondrial"
FT                   /id="PRO_0000115241"
SQ   SEQUENCE   231 AA;  26224 MW;  D76237261DDE6C0D CRC64;
     MSAQKLYASH VPLAPLSRML LGIGSAVTAI SDPKRGDMVA AMGETTAIGP VLENIRKRME
     SDVVGKRLLL EKPRISNGTI DRKWLRQLPD GTLGKLYSNF LDRLNTSPDA RPTVKYIDNL
     EHLYVMQRYR ETHDFTHIAL EQKTNMLGEV TVKYFEGIQY GLPMCVTGGI FGGARLLTKN
     RQELVDRNLP WVVEQATNAR FFMAFDWENH FEKQLSEVQK ELNITPLSVN M