ID   COQ4_CANDC              Reviewed;         323 AA.
AC   B9W797;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   Name=COQ4 {ECO:0000255|HAMAP-Rule:MF_03111}; ORFNames=CD36_02960;
OS   Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 /
OS   NRRL Y-17841) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=573826;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841;
RX   PubMed=19745113; DOI=10.1101/gr.097501.109;
RA   Jackson A.P., Gamble J.A., Yeomans T., Moran G.P., Saunders D., Harris D.,
RA   Aslett M., Barrell J.F., Butler G., Citiulo F., Coleman D.C.,
RA   de Groot P.W.J., Goodwin T.J., Quail M.A., McQuillan J., Munro C.A.,
RA   Pain A., Poulter R.T., Rajandream M.A., Renauld H., Spiering M.J.,
RA   Tivey A., Gow N.A.R., Barrell B., Sullivan D.J., Berriman M.;
RT   "Comparative genomics of the fungal pathogens Candida dubliniensis and
RT   Candida albicans.";
RL   Genome Res. 19:2231-2244(2009).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; FM992688; CAX44556.1; -; Genomic_DNA.
DR   RefSeq; XP_002416968.1; XM_002416923.1.
DR   AlphaFoldDB; B9W797; -.
DR   SMR; B9W797; -.
DR   STRING; 42374.XP_002416968.1; -.
DR   EnsemblFungi; CAX44556; CAX44556; CD36_02960.
DR   GeneID; 8044504; -.
DR   KEGG; cdu:CD36_02960; -.
DR   CGD; CAL0000164064; Cd36_02960.
DR   VEuPathDB; FungiDB:CD36_02960; -.
DR   eggNOG; KOG3244; Eukaryota.
DR   HOGENOM; CLU_061241_0_2_1; -.
DR   OrthoDB; 1264469at2759; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000002605; Chromosome 1.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Transit peptide;
KW   Ubiquinone biosynthesis.
FT   TRANSIT         1..29
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           30..323
FT                   /note="Ubiquinone biosynthesis protein COQ4, mitochondrial"
FT                   /id="PRO_0000388104"
SQ   SEQUENCE   323 AA;  37664 MW;  0DAE4EFBE2B635FF CRC64;
     MLKSTVSNTR IKCCRIDQRR NYLFTALASS ALGSFLWSKN NVLASKMENG ELHYHDPNLT
     FNKKLFNGKP PFERRAPDYP GHVPLYNFEK VLMFLGSSMG AFFHPEENKY IVALGESTAI
     TPILQHLRHK MLSDPVGRTI LREKPRMTSD SLNLTYLRSL PDNTIGKNYV NWLDKENVSP
     DTRVPVRYID NEELAYIYQR YRECHDFYHA ITGLPIIIEG EIAVKVFEFA NIGIPMSGLG
     ALFAPLRLKP SQRQRLREIY YPWAIKNGLF SKPLINVYWE KILEKDVNEF RQEMGIQQPP
     DLRNMRKEYF AKKKLEKQLQ GRK