ID   COQ4_CANTT              Reviewed;         321 AA.
AC   C5MFD6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
GN   Name=COQ4 {ECO:0000255|HAMAP-Rule:MF_03111}; ORFNames=CTRG_04779;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; GG692400; EER31996.1; -; Genomic_DNA.
DR   RefSeq; XP_002550481.1; XM_002550435.1.
DR   AlphaFoldDB; C5MFD6; -.
DR   SMR; C5MFD6; -.
DR   STRING; 5482.XP_002550481.1; -.
DR   EnsemblFungi; EER31996; EER31996; CTRG_04779.
DR   GeneID; 8298132; -.
DR   KEGG; ctp:CTRG_04779; -.
DR   VEuPathDB; FungiDB:CTRG_04779; -.
DR   eggNOG; KOG3244; Eukaryota.
DR   HOGENOM; CLU_061241_0_2_1; -.
DR   OrthoDB; 1264469at2759; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..321
FT                   /note="Ubiquinone biosynthesis protein COQ4, mitochondrial"
FT                   /id="PRO_0000388106"
SQ   SEQUENCE   321 AA;  37471 MW;  52A7F1F11D99CEDC CRC64;
     MLRTAIRNNV QVSQKRTYIM STIASTFLGS ILFSKNNQLA SKMENGELHM PKDPTLSYLN
     NNNSNNQAEP YFKRREPDYP GHVPLYNYEK FLMFLGSSIG SFFHPEENKY IVALGESTAI
     EPILKKLQKT MLSDEIGRQI LKEKPRITST SLNLDYLRSL PDNTIGKNYI NWLDKEGVSP
     DTRVQVKYID NEELSYIFQR YRECHDFYHA ITGLPIIIEG EISVKVFEFM NIGIPMTGLG
     ALFAPLRLKS SQRKRLREIY YPWAIKNGIY SKPLINVYWE KILEQDVDEF RKQMGIETPP
     DLRNMRKEYF ARKKLEKQGK L