COQ4_CHAGB
ID COQ4_CHAGB Reviewed; 234 AA.
AC Q2H4H9;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Ubiquinone biosynthesis protein COQ4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
GN Name=COQ4 {ECO:0000255|HAMAP-Rule:MF_03111}; ORFNames=CHGG_06436;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC role in organizing a multi-subunit COQ enzyme complex required for
CC coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
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DR EMBL; CH408031; EAQ89817.1; -; Genomic_DNA.
DR RefSeq; XP_001222531.1; XM_001222530.1.
DR AlphaFoldDB; Q2H4H9; -.
DR SMR; Q2H4H9; -.
DR STRING; 38033.XP_001222531.1; -.
DR EnsemblFungi; EAQ89817; EAQ89817; CHGG_06436.
DR GeneID; 4391445; -.
DR eggNOG; KOG3244; Eukaryota.
DR HOGENOM; CLU_1184897_0_0_1; -.
DR InParanoid; Q2H4H9; -.
DR OrthoDB; 1264469at2759; -.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03111; Coq4; 1.
DR InterPro; IPR007715; Coq4.
DR InterPro; IPR027540; Coq4_euk.
DR PANTHER; PTHR12922; PTHR12922; 1.
DR Pfam; PF05019; Coq4; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Ubiquinone biosynthesis.
FT CHAIN 1..234
FT /note="Ubiquinone biosynthesis protein COQ4, mitochondrial"
FT /id="PRO_0000388107"
FT REGION 12..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 234 AA; 26309 MW; 213913DC13D1AD90 CRC64;
MANKFPFWAA AISSQQQQPS DPPQQHSLQA PNSRSLLPSR SLTRPAGPTT LGHDLIAAFA
EATATPYFIY RLRDAMLASP TGRRILRDRP RITSTSLNLP YLRSLPPGTV GHTYVAWLDR
EGVSPDTRSA VRYIDDAECA YVMQRYRECH DFYHALTGLP VVREGEVALK AFEFANTLLP
MTGLSVFAAA TLKRSERRRF GEIYLPWALR NGLRAAEVIN MYWEEPLERD VVGS