ID   COQ4_COCP7              Reviewed;         283 AA.
AC   C5PIQ6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   Name=COQ4 {ECO:0000255|HAMAP-Rule:MF_03111}; ORFNames=CPC735_057790;
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; ACFW01000049; EER24409.1; -; Genomic_DNA.
DR   RefSeq; XP_003066554.1; XM_003066508.1.
DR   AlphaFoldDB; C5PIQ6; -.
DR   SMR; C5PIQ6; -.
DR   EnsemblFungi; EER24409; EER24409; CPC735_057790.
DR   GeneID; 9692024; -.
DR   KEGG; cpw:CPC735_057790; -.
DR   VEuPathDB; FungiDB:CPC735_057790; -.
DR   HOGENOM; CLU_061241_0_0_1; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Transit peptide;
KW   Ubiquinone biosynthesis.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           26..283
FT                   /note="Ubiquinone biosynthesis protein COQ4, mitochondrial"
FT                   /id="PRO_0000388110"
SQ   SEQUENCE   283 AA;  32250 MW;  21CDE31D0F06E7DA CRC64;
     MAIAKSVRAR AVGLRSLRVL CAQRSVAREF SVLNRPQPNY PGHIPLTPIE RGALAIGSAV
     GSLLNPRRGD LIATVGETTA TPFFIYRLRD AMLADSTGRR ILRDRPRITS QTLSLPYLRN
     LPKNTVGYTY ATWLDREGVS PDTRSSVQYI DDEECAYVMQ RYRECHDFYH AVTGLPIVVE
     GEIALKAFEF MNTLIPMTGL SVFAAIRLKP EEKQRFWSIH LPWAIRSGLA SKELINVYWE
     EQLERDVNEL REELNIEKPP DLRDIRKKVR EQKKAAKEAV IKS