ID   COQ4_CRYPI              Reviewed;         305 AA.
AC   Q5CT19;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
GN   ORFNames=cgd1_380;
OS   Cryptosporidium parvum (strain Iowa II).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX   NCBI_TaxID=353152;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Iowa II;
RX   PubMed=15044751; DOI=10.1126/science.1094786;
RA   Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA   Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA   Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA   Anantharaman V., Aravind L., Kapur V.;
RT   "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL   Science 304:441-445(2004).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; AAEE01000006; EAK88604.1; -; Genomic_DNA.
DR   RefSeq; XP_627898.1; XM_627898.1.
DR   AlphaFoldDB; Q5CT19; -.
DR   SMR; Q5CT19; -.
DR   STRING; 353152.Q5CT19; -.
DR   EnsemblProtists; EAK88604; EAK88604; cgd1_380.
DR   GeneID; 3371528; -.
DR   KEGG; cpv:cgd1_380; -.
DR   VEuPathDB; CryptoDB:cgd1_380; -.
DR   InParanoid; Q5CT19; -.
DR   OMA; KFFEFAN; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000006726; Chromosome 1.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..305
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388075"
SQ   SEQUENCE   305 AA;  35648 MW;  5B10196B27C666DD CRC64;
     MNKFTNLLIK RTASSLKGGD FRELFRKNYI PITQFEKVLL SVTSCVEGLK NPTDSNSVAC
     ITELTSNRAL RRLQILMNST PDGRRIIKNR PLIDSSKYSI KDLMAFPDDS LGRRYGEFLT
     TYNLEINRDP VRYVNSEDLA YVLTRFRQIH DILHTAFELN ITVESEVTLK LFEFLHAGIP
     FGAIGAFMGL FITPILKVRP KEIFENHNKT HVYPSKPIQI HQDCDKYLNS LEITKKEILY
     PKRIVIKELI PWIYKAEKKM RHNIYTIMVE DWFPRPIADF QNYLNISPPP KQLQKYTRIK
     PMPFC