COQ4_DROME
ID COQ4_DROME Reviewed; 268 AA.
AC Q9VVG6; B7Z065;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
GN Name=Coq4 {ECO:0000312|FlyBase:FBgn0052174};
GN ORFNames=CG32174 {ECO:0000312|FlyBase:FBgn0052174};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAF49345.3};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC role in organizing a multi-subunit COQ enzyme complex required for
CC coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
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DR EMBL; AE014296; AAF49345.3; -; Genomic_DNA.
DR EMBL; AE014296; ACL83318.1; -; Genomic_DNA.
DR RefSeq; NP_001246815.1; NM_001259886.1.
DR RefSeq; NP_648977.3; NM_140720.5.
DR RefSeq; NP_730270.1; NM_168732.3.
DR AlphaFoldDB; Q9VVG6; -.
DR SMR; Q9VVG6; -.
DR STRING; 7227.FBpp0298344; -.
DR PaxDb; Q9VVG6; -.
DR PRIDE; Q9VVG6; -.
DR DNASU; 261607; -.
DR EnsemblMetazoa; FBtr0075227; FBpp0074989; FBgn0052174.
DR EnsemblMetazoa; FBtr0299819; FBpp0289097; FBgn0052174.
DR EnsemblMetazoa; FBtr0307343; FBpp0298344; FBgn0052174.
DR GeneID; 261607; -.
DR KEGG; dme:Dmel_CG32174; -.
DR UCSC; CG32174-RB; d. melanogaster.
DR CTD; 51117; -.
DR FlyBase; FBgn0052174; Coq4.
DR VEuPathDB; VectorBase:FBgn0052174; -.
DR eggNOG; KOG3244; Eukaryota.
DR GeneTree; ENSGT00390000003828; -.
DR HOGENOM; CLU_061241_1_1_1; -.
DR InParanoid; Q9VVG6; -.
DR OMA; KFFEFAN; -.
DR PhylomeDB; Q9VVG6; -.
DR UniPathway; UPA00232; -.
DR BioGRID-ORCS; 261607; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Coq4; fly.
DR GenomeRNAi; 261607; -.
DR PRO; PR:Q9VVG6; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0052174; Expressed in Malpighian tubule and 12 other tissues.
DR ExpressionAtlas; Q9VVG6; differential.
DR Genevisible; Q9VVG6; DM.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; ISS:UniProtKB.
DR HAMAP; MF_03111; Coq4; 1.
DR InterPro; IPR007715; Coq4.
DR InterPro; IPR027540; Coq4_euk.
DR PANTHER; PTHR12922; PTHR12922; 1.
DR Pfam; PF05019; Coq4; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Ubiquinone biosynthesis.
FT CHAIN 1..268
FT /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT mitochondrial"
FT /id="PRO_0000115242"
SQ SEQUENCE 268 AA; 30743 MW; EB64960D9B98A08F CRC64;
MMQRCLRLQK PLALRRGLRL AQANSQAVAT EAPEAEPLDA FERQYLKERI EISPFQRLFL
GAGSSIAALL NPRRHDMIAC LGETTGEDAL WTILDTMQAS EEGQRIMADK PRIHTSTIDF
KYLETLPPDT FGAAYVKFLK DNQVTPDSRM AVRFLEDPKL AYLMTRYREC HDLIHTVLDM
PTNMLGEVAV KWVEALNTGL PMCYGGAVFG AVRLRPKQRR AYLKHYLPWA LENGKRTKPL
MPVYWEKRWE QNIHELRSEL GITVLNKA
