ID   COQ4_DROPS              Reviewed;         267 AA.
AC   Q2LZH7;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 3.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
GN   ORFNames=GA16732;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL29530.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CH379069; EAL29530.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_015043171.1; XM_015187685.1.
DR   AlphaFoldDB; Q2LZH7; -.
DR   SMR; Q2LZH7; -.
DR   STRING; 7237.FBpp0275319; -.
DR   EnsemblMetazoa; FBtr0373434; FBpp0335217; FBgn0076747.
DR   GeneID; 4813856; -.
DR   KEGG; dpo:Dpse_GA16732; -.
DR   eggNOG; KOG3244; Eukaryota.
DR   InParanoid; Q2LZH7; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000001819; Chromosome X.
DR   Bgee; FBgn0076747; Expressed in insect adult head and 2 other tissues.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..267
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388066"
SQ   SEQUENCE   267 AA;  30806 MW;  7F5EF3B10B30ECEC CRC64;
     MMQRCWRLPV PLGKRGLAVV THTRQAVVSD NPEAENLDGF EQQYLKERIE ITTFQRMLLG
     AGSSIAAILD PRRHDMIACL GETTGEDALW NIMDTMHESE EGQRIMVEKP RIHTSTIDFK
     RLESLPADTF GAAYVKFLKD NKVTPDSRMA VRFLEDPKLA YLMTRYRECH DLIHTVLDMP
     TNMLGEVAVK WVEALNTGLP MCYGGAVFGA VRLRPKQRRA YLKHYLPWAL ENGKQMKPLM
     PVYWEERWEQ NVNELRAELG IKLLNKF