ID   COQ4_DROSI              Reviewed;         268 AA.
AC   B4QNU8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   ORFNames=GD12405;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDX10850.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CM000363; EDX10850.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_016032290.1; XM_016169341.1.
DR   AlphaFoldDB; B4QNU8; -.
DR   SMR; B4QNU8; -.
DR   STRING; 7240.B4QNU8; -.
DR   EnsemblMetazoa; FBtr0354409; FBpp0318795; FBgn0184137.
DR   GeneID; 6738458; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000000304; Chromosome 3l.
DR   Bgee; FBgn0184137; Expressed in embryo and 3 other tissues.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Ubiquinone biosynthesis.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           26..268
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388068"
SQ   SEQUENCE   268 AA;  30752 MW;  0645AF036F3A7EA9 CRC64;
     MMQRCLRLQK PLALRRGLHL AQVNSQAVAT EAPEAEPLDA FERQYLKERI EISPFQRLFL
     GTGSSIAALL NPRRHDMIAC LGETTGEDAL WTILDTMQAS EEGQRIMADK PRIHTSTIDF
     KYLETLPPDT FGAAYVKFLK DNQVTPDSRM AVRFLEDPKL AYLMTRYREC HDLIHTVLDM
     PTNMLGEVAV KWVEALNTGL PMCYGGAVFG AVRLRPKQRR AYLKHYLPWA LENGKRAKPL
     MPVYWEKRWE QNIHELRSEL GITVLNKA