ID   COQ4_DROWI              Reviewed;         265 AA.
AC   B4N6G2;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
GN   ORFNames=GK18052;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; CH964154; EDW79951.1; -; Genomic_DNA.
DR   RefSeq; XP_002068965.2; XM_002068929.2.
DR   AlphaFoldDB; B4N6G2; -.
DR   SMR; B4N6G2; -.
DR   STRING; 7260.FBpp0247195; -.
DR   GeneID; 6646144; -.
DR   KEGG; dwi:6646144; -.
DR   eggNOG; KOG3244; Eukaryota.
DR   HOGENOM; CLU_061241_1_1_1; -.
DR   InParanoid; B4N6G2; -.
DR   OMA; KFFEFAN; -.
DR   PhylomeDB; B4N6G2; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..265
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388070"
SQ   SEQUENCE   265 AA;  30679 MW;  0092D57B44AD592A CRC64;
     MMQRLRLARR GLALSAVRRQ TVVPEEEPLD AYEREHLKHR IEITPFQRML LGAGSSVAAI
     LDPRRHDMIA CLGETTGEGA LWNILDTMEA SEEGQRILID KPRIHTSTID FKRLETLPPD
     TFGAAYVKFL KDNNVTPDSR MPVRFLEDPK LAYLMTRYRE CHDLIHTVLN MPTNMLGEVA
     VKWVEALNTN LPMCYGGAVF GAVRLRPKQR REYLKRYLPW AIDNGKRMKP LMPVYWEQRW
     EQNLDLAKKT SPIMLPALRI TRRDG