ID   COQ4_PARBP              Reviewed;         285 AA.
AC   C0SDJ3;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   Name=COQ4 {ECO:0000255|HAMAP-Rule:MF_03111}; ORFNames=PABG_05748;
OS   Paracoccidioides brasiliensis (strain Pb03).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=482561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb03;
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; KN305539; EEH23537.2; -; Genomic_DNA.
DR   AlphaFoldDB; C0SDJ3; -.
DR   SMR; C0SDJ3; -.
DR   EnsemblFungi; EEH23537; EEH23537; PABG_05748.
DR   VEuPathDB; FungiDB:PABG_05748; -.
DR   HOGENOM; CLU_061241_0_0_1; -.
DR   InParanoid; C0SDJ3; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000002740; Unassembled WGS sequence.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Transit peptide;
KW   Ubiquinone biosynthesis.
FT   TRANSIT         1..11
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           12..285
FT                   /note="Ubiquinone biosynthesis protein COQ4, mitochondrial"
FT                   /id="PRO_0000388124"
SQ   SEQUENCE   285 AA;  32734 MW;  63D39E67441936DE CRC64;
     MPPTVRQGIR TVGTLRVTRP SSYVLSSREF SVLNRPPPNY PGHIPLTTIE RGALAVGSAI
     GSLLNPRRAD LIAALGEATA TPYFIYRLRD AMLSNPTGRR ILRDRPRISS KTLSVEYLRS
     LPPNSVGRTY VSWLDREGVG PDSRETVRYI DDEECAYVMQ RYRECHDFYH AVTGLPIVVE
     GEVALKTFEF ANTLLPMTGL SMFAVMRLKP EERERYWELH LPWAVRSGLA SKEVINVYWE
     EELERDVNEL REKLGIEKPP DLREIRKMMR RQKKAAEAAR EKYQN