COQ4_PICST
ID COQ4_PICST Reviewed; 320 AA.
AC A3LXH5;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Ubiquinone biosynthesis protein COQ4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
DE Flags: Precursor;
GN Name=COQ4 {ECO:0000255|HAMAP-Rule:MF_03111}; ORFNames=PICST_90569;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC role in organizing a multi-subunit COQ enzyme complex required for
CC coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
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DR EMBL; CP000500; ABN67459.2; -; Genomic_DNA.
DR RefSeq; XP_001385488.2; XM_001385451.1.
DR AlphaFoldDB; A3LXH5; -.
DR SMR; A3LXH5; -.
DR STRING; 4924.XP_001385488.2; -.
DR EnsemblFungi; ABN67459; ABN67459; PICST_90569.
DR GeneID; 4840366; -.
DR KEGG; pic:PICST_90569; -.
DR eggNOG; KOG3244; Eukaryota.
DR HOGENOM; CLU_061241_0_2_1; -.
DR InParanoid; A3LXH5; -.
DR OMA; KFFEFAN; -.
DR OrthoDB; 1264469at2759; -.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000002258; Chromosome 6.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03111; Coq4; 1.
DR InterPro; IPR007715; Coq4.
DR InterPro; IPR027540; Coq4_euk.
DR PANTHER; PTHR12922; PTHR12922; 1.
DR Pfam; PF05019; Coq4; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Ubiquinone biosynthesis.
FT TRANSIT 1..31
FT /note="Mitochondrion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT CHAIN 32..320
FT /note="Ubiquinone biosynthesis protein COQ4, mitochondrial"
FT /id="PRO_0000388131"
SQ SEQUENCE 320 AA; 36844 MW; EDA5FA9216E23049 CRC64;
MFARSALGRS DQLVTALNSQ KRQFVLTAAT TALGSLLFSE DNRLASQMEK GLLHNKNAEN
SASIPNTANK FFSRPEAEYP GHVPLYTFEK MLMFLGSSVG AYTHPERNEF IVALGESTAI
TPVLRRLQHQ MLSDPVGRQI LRERPRMTST SLDLEHLREL PDNTIGKTYV KWLDKEGVSP
DTRVEVKYID NEELAYIYQR YRECHDFYHA ITGLPIIIEG EISVKVFEYM NIGIPMSGLG
ALFAPLRLKK SQKERLYNIY YPWAFKSGLN SKPLINVYWE NILEEDIDEF RKTMGIEQPP
DLRNLRKEYF KKLKEAKKIV
