ID   COQ4_PLAF7              Reviewed;         355 AA.
AC   Q8IIP1; A0A143ZYI5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
GN   Name=COQ4 {ECO:0000305}; ORFNames=PF11_0128, PF3D7_1112200;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LN999945; CZT98782.1; -; Genomic_DNA.
DR   RefSeq; XP_001347800.1; XM_001347764.1.
DR   AlphaFoldDB; Q8IIP1; -.
DR   STRING; 5833.PF11_0128; -.
DR   EnsemblProtists; CZT98782; CZT98782; PF3D7_1112200.
DR   GeneID; 810676; -.
DR   KEGG; pfa:PF3D7_1112200; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1112200; -.
DR   HOGENOM; CLU_781859_0_0_1; -.
DR   InParanoid; Q8IIP1; -.
DR   OMA; QIHDIGH; -.
DR   PhylomeDB; Q8IIP1; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000001450; Chromosome 11.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 2.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..355
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388079"
SQ   SEQUENCE   355 AA;  43053 MW;  660D0361E39D6847 CRC64;
     MYNFVKIFQS NFIDINKLSK FEIFLKTIFR IYSSPGRTHL LAHAADISAK YAVRKIYEYM
     RTDEEGIRIL KEKPLLIRQD ICFNELKKLP KNTLGYKYME FLETYKLHAH DREVSHFIKD
     INESYILTRY RQIHDIAHVV YNLNISIEAE AALKLIELIQ TKLPITLLAI LIAPFMTPLY
     RFQYIFEHNI PSNFLCPNFD YTYNDDYNYI DEMSLKQYEY YLTDYFHVEK RESQSFYYKL
     YKYYFDNLNN SSHVRGSIIY GYQNKNYNDI HYDKLNNEYL YLKNNIKNYF HFQYKPRKLL
     LTNLYPWAYK TAIQTNKPLH SIYVEKWFDK DIDLFRKKYN ITPLPSNLNL MAGIN