ID   COQ4_PLAKH              Reviewed;         355 AA.
AC   B3L4S4;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
GN   ORFNames=PKH_090950;
OS   Plasmodium knowlesi (strain H).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H;
RX   PubMed=18843368; DOI=10.1038/nature07306;
RA   Pain A., Boehme U., Berry A.E., Mungall K., Finn R.D., Jackson A.P.,
RA   Mourier T., Mistry J., Pasini E.M., Aslett M.A., Balasubrammaniam S.,
RA   Borgwardt K., Brooks K., Carret C., Carver T.J., Cherevach I.,
RA   Chillingworth T., Clark T.G., Galinski M.R., Hall N., Harper D., Harris D.,
RA   Hauser H., Ivens A., Janssen C.S., Keane T., Larke N., Lapp S., Marti M.,
RA   Moule S., Meyer I.M., Ormond D., Peters N., Sanders M., Sanders S.,
RA   Sargeant T.J., Simmonds M., Smith F., Squares R., Thurston S., Tivey A.R.,
RA   Walker D., White B., Zuiderwijk E., Churcher C., Quail M.A., Cowman A.F.,
RA   Turner C.M.R., Rajandream M.A., Kocken C.H.M., Thomas A.W., Newbold C.I.,
RA   Barrell B.G., Berriman M.;
RT   "The genome of the simian and human malaria parasite Plasmodium knowlesi.";
RL   Nature 455:799-803(2008).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; AM910991; CAQ39895.1; -; Genomic_DNA.
DR   RefSeq; XP_002259122.1; XM_002259086.1.
DR   AlphaFoldDB; B3L4S4; -.
DR   STRING; 5851.B3L4S4; -.
DR   EnsemblProtists; CAQ39895; CAQ39895; PKH_090950.
DR   GeneID; 7320684; -.
DR   KEGG; pkn:PKNH_0909900; -.
DR   VEuPathDB; PlasmoDB:PKNH_0909900; -.
DR   HOGENOM; CLU_781859_0_0_1; -.
DR   InParanoid; B3L4S4; -.
DR   OMA; QIHDIGH; -.
DR   PhylomeDB; B3L4S4; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000031513; Chromosome 9.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..355
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388080"
SQ   SEQUENCE   355 AA;  42437 MW;  F939F02BDBD90B86 CRC64;
     MYNFVKIFRS NFIDINAANK LEIFLKTILR IYKTPARTHL LAHAADISAI YAVREIYNYM
     KNDEEGRIIL KEKPLLIRQD IQFNELKKLP KNTLGYKYME FLETYKLHAH DREVSHFFTD
     LNYSYILTRY RQIHDIGHVV YNLNISIESE AALKVIELVQ TKLPITALAI LIAPLMTPLY
     RFQYIFKDSI PSNFLTPNFD YTYNDAYNYV DELSIKQYEY NLTDYFHVDK RDDQKFYSKM
     YQYYLDNINN SSAVRGSIIY GFENKSNNDI IYDHPNREYI FLKNLKKKHL LFQYKPRKNL
     LRELYPWAYM AGVSTTKPLH SIHIEKWLDK DIDLFRRTYN ISPLPDHLNL MAGIN