ID   COQ4_PLAVS              Reviewed;         355 AA.
AC   A5K4D8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
GN   ORFNames=PVX_091260;
OS   Plasmodium vivax (strain Salvador I).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=126793;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Salvador I;
RX   PubMed=18843361; DOI=10.1038/nature07327;
RA   Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA   Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q.,
RA   Coulson R.M.R., Crabb B.S., del Portillo H.A., Essien K., Feldblyum T.V.,
RA   Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA   Kooij T.W.A., Korsinczky M., Meyer E.V.-S., Nene V., Paulsen I., White O.,
RA   Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA   Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA   Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT   "Comparative genomics of the neglected human malaria parasite Plasmodium
RT   vivax.";
RL   Nature 455:757-763(2008).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; AAKM01000005; EDL45516.1; -; Genomic_DNA.
DR   RefSeq; XP_001615243.1; XM_001615193.1.
DR   AlphaFoldDB; A5K4D8; -.
DR   STRING; 126793.A5K4D8; -.
DR   EnsemblProtists; EDL45516; EDL45516; PVX_091260.
DR   GeneID; 5474539; -.
DR   KEGG; pvx:PVX_091260; -.
DR   VEuPathDB; PlasmoDB:PVX_091260; -.
DR   InParanoid; A5K4D8; -.
DR   OMA; QIHDIGH; -.
DR   PhylomeDB; A5K4D8; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000008333; Chromosome 9.
DR   Proteomes; UP000008333; Unassembled WGS sequence.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..355
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388081"
SQ   SEQUENCE   355 AA;  42461 MW;  08AFD27D35627131 CRC64;
     MHNFAKIFRS NFIDINAANK FEIFLKTILR IYKTPARTHL LAHAADISAI YAVRQIYNYM
     KNDEEGRTVL KEKPLLIRQD IQFNELKKLP KNTLGYKYMK FLETYKLHAH DREVSHFFTD
     LNYSYILTRY RQIHDIGHVV YNLNISIESE AALKLIELVQ TKLPITLLAI LVAPFMTPIY
     RFQYIFKDSL PSNFLSPNFD FTYTDAYNYV DELSIKQYEY NLTDYFHVEK RNDRNFYTKM
     YQHYFDNINN SSAVRGSIIY GFENKSSNDI IYDQPNREYI FLKNLKKKYL LFQYKPRKNL
     LRELYPWAYM AGVSTTKPLH SIHIEKWLDK DIDLFRRTYN ISPLPDHLNL MAGIN