ID   COQ4_PODAN              Reviewed;         301 AA.
AC   B2AU15; A0A090CFN4;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   Name=COQ4 {ECO:0000255|HAMAP-Rule:MF_03111}; OrderedLocusNames=Pa_1_17660;
GN   ORFNames=PODANS_1_17660;
OS   Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS   (Pleurage anserina).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC   Podospora anserina.
OX   NCBI_TaxID=515849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX   PubMed=18460219; DOI=10.1186/gb-2008-9-5-r77;
RA   Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M.,
RA   Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V.,
RA   Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M.,
RA   Contamine V., Arnaise S., Bourdais A., Berteaux-Lecellier V., Gautheret D.,
RA   de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B.,
RA   El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H.,
RA   Debuchy R., Wincker P., Weissenbach J., Silar P.;
RT   "The genome sequence of the model ascomycete fungus Podospora anserina.";
RL   Genome Biol. 9:R77.1-R77.22(2008).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX   PubMed=24558260; DOI=10.1534/genetics.113.159988;
RA   Grognet P., Bidard F., Kuchly C., Tong L.C.H., Coppin E., Benkhali J.A.,
RA   Couloux A., Wincker P., Debuchy R., Silar P.;
RT   "Maintaining two mating types: Structure of the mating type locus and its
RT   role in heterokaryosis in Podospora anserina.";
RL   Genetics 197:421-432(2014).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; CU633899; CAP67888.1; -; Genomic_DNA.
DR   EMBL; FO904936; CDP24147.1; -; Genomic_DNA.
DR   RefSeq; XP_001907217.1; XM_001907182.1.
DR   AlphaFoldDB; B2AU15; -.
DR   SMR; B2AU15; -.
DR   STRING; 515849.B2AU15; -.
DR   EnsemblFungi; CAP67888; CAP67888; PODANS_1_17660.
DR   GeneID; 6191276; -.
DR   KEGG; pan:PODANSg4250; -.
DR   VEuPathDB; FungiDB:PODANS_1_17660; -.
DR   eggNOG; KOG3244; Eukaryota.
DR   HOGENOM; CLU_061241_0_0_1; -.
DR   OrthoDB; 1264469at2759; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000001197; Chromosome 1.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Ubiquinone biosynthesis.
FT   TRANSIT         1..46
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           47..301
FT                   /note="Ubiquinone biosynthesis protein COQ4, mitochondrial"
FT                   /id="PRO_0000388132"
FT   REGION          14..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   301 AA;  34488 MW;  5B01154F9AD36D98 CRC64;
     MEVTLKRSAA LARQTTPLLR PLRPVATYPS NNNNNNNPTP QQRRPYSLFS SLTRPPPNYP
     GHVPLSFVEK TALAIGSGLI SLKNPRRGDL IATFAETTST PYFIYRLRDA MLSSPTGRRI
     LRDRPRITST SLNLPYLRSL PPNTVGHTYI SWLDREGVSP DTRSPVRYID DEECAYVMQR
     YRECHDFYHA LTGLPVVREG EVALKAFEFA NTLLPMTGLS VFSLVGMKKK ERERFWGVYG
     PWAVRNGLRA KEVINVYWEE VLEKDVGELR KELGVEVPAD LREMRRRERE EKKRREAAAR
     G