ID   COQ4_RAT                Reviewed;         265 AA.
AC   Q4FZU1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   Name=Coq4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; BC099123; AAH99123.1; -; mRNA.
DR   RefSeq; NP_001026832.1; NM_001031662.1.
DR   AlphaFoldDB; Q4FZU1; -.
DR   SMR; Q4FZU1; -.
DR   STRING; 10116.ENSRNOP00000038869; -.
DR   iPTMnet; Q4FZU1; -.
DR   PhosphoSitePlus; Q4FZU1; -.
DR   PaxDb; Q4FZU1; -.
DR   PRIDE; Q4FZU1; -.
DR   GeneID; 366013; -.
DR   KEGG; rno:366013; -.
DR   UCSC; RGD:1304638; rat.
DR   CTD; 51117; -.
DR   RGD; 1304638; Coq4.
DR   eggNOG; KOG3244; Eukaryota.
DR   HOGENOM; CLU_061241_1_1_1; -.
DR   InParanoid; Q4FZU1; -.
DR   OrthoDB; 1264469at2759; -.
DR   PhylomeDB; Q4FZU1; -.
DR   TreeFam; TF314625; -.
DR   UniPathway; UPA00232; -.
DR   PRO; PR:Q4FZU1; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q4FZU1; RN.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0110142; C:ubiquinone biosynthesis complex; ISO:RGD.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein;
KW   Reference proteome; Transit peptide; Ubiquinone biosynthesis.
FT   TRANSIT         1..29
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           30..265
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000320292"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3A0"
SQ   SEQUENCE   265 AA;  30013 MW;  EA1EDF4BBFDEF39B CRC64;
     MATLLLRSQR LHRSLRHRTR PTVDVLLRAA SHGARLLYPD HIPTTPLQKM LLAAGAAGMA
     LYNPYRHDMV AVLGETTGCH TLKFLRDQMK KDPEGAQILQ ERPRISLSTL DLSKLQSLPE
     GSLGREYLRF LNANKVSPDT RAPTRFVDDE ELAYVIQRYR EVHDMLHTLL GMPTNMLGEV
     VVKWFEAVQT GLPMCILGAL FGPVRLRAQS LQVLFSELIP WAIQNGRRAP CVLNIYYEQR
     WEQPLTALRE ELGISPPPKH IQGLA