COQ4_SCHPO
ID COQ4_SCHPO Reviewed; 272 AA.
AC O94453;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Ubiquinone biosynthesis protein coq4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
GN Name=coq4; ORFNames=SPAC1687.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC role in organizing a multi-subunit COQ enzyme complex required for
CC coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_03111}.
CC -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC at least coq3, coq4, coq5, coq6, coq7 and coq9. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_03111, ECO:0000269|PubMed:16823372}; Peripheral membrane
CC protein {ECO:0000255|HAMAP-Rule:MF_03111, ECO:0000269|PubMed:16823372};
CC Matrix side {ECO:0000255|HAMAP-Rule:MF_03111,
CC ECO:0000269|PubMed:16823372}.
CC -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
CC -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC Rule:MF_03111}.
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DR EMBL; CU329670; CAA22606.1; -; Genomic_DNA.
DR PIR; T37755; T37755.
DR RefSeq; NP_593130.1; NM_001018526.2.
DR AlphaFoldDB; O94453; -.
DR SMR; O94453; -.
DR BioGRID; 278121; 2.
DR STRING; 4896.SPAC1687.12c.1; -.
DR MaxQB; O94453; -.
DR PaxDb; O94453; -.
DR EnsemblFungi; SPAC1687.12c.1; SPAC1687.12c.1:pep; SPAC1687.12c.
DR GeneID; 2541625; -.
DR KEGG; spo:SPAC1687.12c; -.
DR PomBase; SPAC1687.12c; coq4.
DR VEuPathDB; FungiDB:SPAC1687.12c; -.
DR eggNOG; KOG3244; Eukaryota.
DR HOGENOM; CLU_061241_0_0_1; -.
DR InParanoid; O94453; -.
DR OMA; KFFEFAN; -.
DR PhylomeDB; O94453; -.
DR UniPathway; UPA00232; -.
DR PRO; PR:O94453; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005739; C:mitochondrion; IDA:PomBase.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IMP:PomBase.
DR HAMAP; MF_03111; Coq4; 1.
DR InterPro; IPR007715; Coq4.
DR InterPro; IPR027540; Coq4_euk.
DR PANTHER; PTHR12922; PTHR12922; 1.
DR Pfam; PF05019; Coq4; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Ubiquinone biosynthesis.
FT CHAIN 1..272
FT /note="Ubiquinone biosynthesis protein coq4, mitochondrial"
FT /id="PRO_0000115244"
SQ SEQUENCE 272 AA; 31100 MW; 26E66EF510EBBAAB CRC64;
MFYLNAHLEI NKVVDVVMSL SKKFLKPSVA SNQLRLLFTA AERKVNYPGH VPLSPLQRIF
LVAGSAIMGL KAPWRGGDMI SVLGDASGQP FFLHRLLNKM LVDKTGREIL KDKPRMTSKS
LNLPFLRTLP PNTLGKIYVD WIDKEHVGPD TRSPTRFVDD PEEAYVMQRY RESHDFYHAI
CNMPTNIEGE LAIKWLEFVN MGLPVGALSA LFGPLRLNCE QASRFRRVYI PWSIRNGLNA
KTLINVYWEK ELTNDIEDVR RRIRIEAAPP LV
