ID   COQ4_TALMQ              Reviewed;         287 AA.
AC   B6QTE1;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Ubiquinone biosynthesis protein coq4, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 {ECO:0000255|HAMAP-Rule:MF_03111};
GN   Name=coq4; ORFNames=PMAA_003700;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least coq3, coq4, coq5, coq6, coq7 and coq9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; DS995905; EEA19582.1; -; Genomic_DNA.
DR   RefSeq; XP_002152519.1; XM_002152483.1.
DR   AlphaFoldDB; B6QTE1; -.
DR   SMR; B6QTE1; -.
DR   STRING; 441960.B6QTE1; -.
DR   EnsemblFungi; EEA19582; EEA19582; PMAA_003700.
DR   GeneID; 7029936; -.
DR   KEGG; tmf:PMAA_003700; -.
DR   VEuPathDB; FungiDB:PMAA_003700; -.
DR   HOGENOM; CLU_061241_0_0_1; -.
DR   OrthoDB; 1264469at2759; -.
DR   PhylomeDB; B6QTE1; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..287
FT                   /note="Ubiquinone biosynthesis protein coq4, mitochondrial"
FT                   /id="PRO_0000388127"
SQ   SEQUENCE   287 AA;  32869 MW;  F2853579451F26FF CRC64;
     MPPPPRTALL AASSRCLKCY EIGLKYASRN FSALNRPLPN YPGHVPLNRI ERGVLAIGSA
     FGSLINPYRH DLIAALGEAT ATPYFIYRLR DAMLSNPTGR RILRDRPRIT SETLKLPYLR
     NLPENSVGWT YAKWLDKEGV TPDSRDSVQY IDDEECAYVM QRYRECHDFY HAVTGLPTMV
     EGELALKAFE FLNTVLPMTG LSLAAVVRLK PAERERFFKL HLPWAVRSGL SSEELINVYW
     EEQLERNVDD LRTELGIETP PDLREIRRMM RQQEKRAKEQ QAQGSSS