ID   COQ4_XENLA              Reviewed;         283 AA.
AC   A9JS49;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
GN   Name=coq4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least coq3, coq4, coq5, coq6, coq7 and coq9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; BC155917; AAI55918.1; -; mRNA.
DR   EMBL; BC169417; AAI69417.1; -; mRNA.
DR   EMBL; BC169419; AAI69419.1; -; mRNA.
DR   RefSeq; NP_001106344.1; NM_001112873.1.
DR   AlphaFoldDB; A9JS49; -.
DR   SMR; A9JS49; -.
DR   GeneID; 100127306; -.
DR   KEGG; xla:100127306; -.
DR   CTD; 100127306; -.
DR   Xenbase; XB-GENE-5888863; coq4.L.
DR   OrthoDB; 1264469at2759; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 100127306; Expressed in muscle tissue and 20 other tissues.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Ubiquinone biosynthesis.
FT   CHAIN           1..283
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388054"
SQ   SEQUENCE   283 AA;  32074 MW;  E17AE2150EB2FAFE CRC64;
     MKILLSCLRF SPVWRGPRSA ACVMQGGKLQ RFQSYNTAEE GIEEDIQFAA TNQESSSLLY
     PDHIPTNAVQ KLLLSAGSAV MALYDPYRHD MVAVLGETTG AVALRKLRDQ MRRDPEGLQI
     LQERPRISTS TLDMQALREM QDGTLGREYA RFLDVNRVTP DTRMPVKFVD DEELAYVAQR
     YREVHDLMHT LLGMPTNMLG EVVVKWFEAV QTGLPMCILG AAFGPLRLNN KRMQKLGVLV
     PWAVQSGRNA RCVLNFHYEN RWEQSVLSLR KEIGILPLPE IKA