ID   COQ4_XENTR              Reviewed;         280 AA.
AC   Q28CM7; B1WBE9; B7ZTY2;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03111};
DE   AltName: Full=Coenzyme Q biosynthesis protein 4 homolog {ECO:0000255|HAMAP-Rule:MF_03111};
DE   Flags: Precursor;
GN   Name=coq4; ORFNames=TEgg106n15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg, Eye, and Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the coenzyme Q biosynthetic pathway. May play a
CC       role in organizing a multi-subunit COQ enzyme complex required for
CC       coenzyme Q biosynthesis. Required for steady-state levels of other COQ
CC       polypeptides. {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SUBUNIT: Component of a multi-subunit COQ enzyme complex, composed of
CC       at least coq3, coq4, coq5, coq6, coq7 and coq9. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03111}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03111}.
CC   -!- SIMILARITY: Belongs to the COQ4 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03111}.
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DR   EMBL; CR926300; CAJ81453.1; -; mRNA.
DR   EMBL; BC161730; AAI61730.1; -; mRNA.
DR   EMBL; BC171035; AAI71035.1; -; mRNA.
DR   RefSeq; NP_001016225.1; NM_001016225.1.
DR   AlphaFoldDB; Q28CM7; -.
DR   SMR; Q28CM7; -.
DR   STRING; 8364.ENSXETP00000008596; -.
DR   PaxDb; Q28CM7; -.
DR   GeneID; 548979; -.
DR   KEGG; xtr:548979; -.
DR   CTD; 51117; -.
DR   Xenbase; XB-GENE-5888837; coq4.
DR   eggNOG; KOG3244; Eukaryota.
DR   HOGENOM; CLU_061241_0_0_1; -.
DR   InParanoid; Q28CM7; -.
DR   OrthoDB; 1264469at2759; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03111; Coq4; 1.
DR   InterPro; IPR007715; Coq4.
DR   InterPro; IPR027540; Coq4_euk.
DR   PANTHER; PTHR12922; PTHR12922; 1.
DR   Pfam; PF05019; Coq4; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Ubiquinone biosynthesis.
FT   TRANSIT         1..15
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03111"
FT   CHAIN           16..280
FT                   /note="Ubiquinone biosynthesis protein COQ4 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000388055"
FT   CONFLICT        3
FT                   /note="G -> V (in Ref. 1; AAI71035)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        25
FT                   /note="Q -> QA (in Ref. 1; AAI71035)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        26
FT                   /note="G -> AS (in Ref. 1; AAI61730)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   280 AA;  31732 MW;  3D12271A360D07CB CRC64;
     MSGLLRYLHC SPAWRVLRPA APGMQGGRFR SNYAAEEGIE EEIQFAAARQ EDPSSLYSDH
     IPTNAVQKLL LSAGSAVMAL YDPYRHDMVA VLGETTGAVA LRKLRDQMRR DPEGLQILQE
     RPRIRMSTLD FQTLREMPDG TFGREYARFL DVNHVTPDTR MPVKFVDDEE LAYVAQRYRE
     VHDLMHTLLG MPTNMLGEVV VKWFEAVQTG LPMCILGAAF GPLRLNNKRM KKLGVLVPWA
     VQSGRNARCV LNFYYEKRWG QSVASLREEI GILPPPEIKA