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COQ7_PSEU2
ID   COQ7_PSEU2              Reviewed;         215 AA.
AC   Q4ZML8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=3-demethoxyubiquinol 3-hydroxylase {ECO:0000255|HAMAP-Rule:MF_01658};
DE            Short=DMQ hydroxylase {ECO:0000255|HAMAP-Rule:MF_01658};
DE            EC=1.14.99.60 {ECO:0000255|HAMAP-Rule:MF_01658};
DE   AltName: Full=2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase {ECO:0000255|HAMAP-Rule:MF_01658};
GN   Name=coq7 {ECO:0000255|HAMAP-Rule:MF_01658}; OrderedLocusNames=Psyr_4574;
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a;
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT   syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- FUNCTION: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-
CC       methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01658}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol +
CC         AH2 + O2 = A + a 3-demethylubiquinol + H2O; Xref=Rhea:RHEA:50908,
CC         Rhea:RHEA-COMP:10859, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:13193,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:84167, ChEBI:CHEBI:84422; EC=1.14.99.60;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01658};
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01658};
CC       Note=Binds 2 iron ions per subunit. {ECO:0000255|HAMAP-Rule:MF_01658};
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_01658}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01658};
CC       Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01658}.
CC   -!- SIMILARITY: Belongs to the COQ7 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01658}.
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DR   EMBL; CP000075; AAY39604.1; -; Genomic_DNA.
DR   RefSeq; WP_011269103.1; NC_007005.1.
DR   RefSeq; YP_237642.1; NC_007005.1.
DR   AlphaFoldDB; Q4ZML8; -.
DR   SMR; Q4ZML8; -.
DR   STRING; 205918.Psyr_4574; -.
DR   EnsemblBacteria; AAY39604; AAY39604; Psyr_4574.
DR   KEGG; psb:Psyr_4574; -.
DR   PATRIC; fig|205918.7.peg.4713; -.
DR   eggNOG; COG2941; Bacteria.
DR   HOGENOM; CLU_088601_0_0_6; -.
DR   OMA; NPLWYGG; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008682; F:3-demethoxyubiquinol 3-hydroxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01042; DMQH; 1.
DR   Gene3D; 1.20.1260.10; -; 1.
DR   HAMAP; MF_01658; COQ7; 1.
DR   InterPro; IPR012347; Ferritin-like.
DR   InterPro; IPR009078; Ferritin-like_SF.
DR   InterPro; IPR011566; Ubq_synth_Coq7.
DR   PANTHER; PTHR11237; PTHR11237; 1.
DR   Pfam; PF03232; COQ7; 1.
DR   SUPFAM; SSF47240; SSF47240; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Iron; Membrane; Metal-binding; Monooxygenase;
KW   Oxidoreductase; Ubiquinone biosynthesis.
FT   CHAIN           1..215
FT                   /note="3-demethoxyubiquinol 3-hydroxylase"
FT                   /id="PRO_0000338720"
FT   REGION          26..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         64
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01658"
FT   BINDING         94
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01658"
FT   BINDING         94
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01658"
FT   BINDING         97
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01658"
FT   BINDING         146
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01658"
FT   BINDING         178
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01658"
FT   BINDING         178
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01658"
FT   BINDING         181
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01658"
SQ   SEQUENCE   215 AA;  23712 MW;  BBEB96F178E1DF9C CRC64;
     MATERQYSPL DRLLLQADSA MRTLLPSSAH SQRPSPAVVQ PEHKMSEADT RHVAGLMRIN
     HTGEVCAQAL YQGQALTAKL PKVRKAMERA AEEEIDHLVW CEQRIHQLGS HTSVLNPLFY
     SLSFGMGAVA GVISDRVSLG FVAATEDQVC KHLAEHLEQL PTEDGKSRAI LQQMLSDEEH
     HAESALEAGG FRFPAPVKFG MSVLAKVMTK STYRI
 
 
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