ID   COQ8_CAEEL              Reviewed;         755 AA.
AC   Q18486;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   11-APR-2003, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Atypical kinase coq-8, mitochondrial {ECO:0000250|UniProtKB:Q8NI60};
DE            EC=2.7.-.- {ECO:0000250|UniProtKB:Q8NI60};
DE   Flags: Precursor;
GN   Name=coq-8; ORFNames=C35D10.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Atypical kinase involved in the biosynthesis of coenzyme Q,
CC       also named ubiquinone, an essential lipid-soluble electron transporter
CC       for aerobic cellular respiration. Its substrate specificity is unclear:
CC       either acts as protein kinase that phosphorylates other proteins in the
CC       CoQ complex to stabilize their interactions or acts as a small molecule
CC       kinase that phosphorylates a prenyl lipid in the ubiquinone
CC       biosynthesis pathway. {ECO:0000250|UniProtKB:Q8NI60}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000250|UniProtKB:Q8NI60}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8NI60}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000305}.
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DR   EMBL; FO080789; CCD66776.1; -; Genomic_DNA.
DR   PIR; S72572; S72572.
DR   RefSeq; NP_498014.2; NM_065613.7.
DR   AlphaFoldDB; Q18486; -.
DR   SMR; Q18486; -.
DR   BioGRID; 40881; 3.
DR   STRING; 6239.C35D10.4; -.
DR   EPD; Q18486; -.
DR   PaxDb; Q18486; -.
DR   PeptideAtlas; Q18486; -.
DR   EnsemblMetazoa; C35D10.4.1; C35D10.4.1; WBGene00000767.
DR   GeneID; 175647; -.
DR   KEGG; cel:CELE_C35D10.4; -.
DR   UCSC; C35D10.4; c. elegans.
DR   CTD; 175647; -.
DR   WormBase; C35D10.4; CE32159; WBGene00000767; coq-8.
DR   eggNOG; KOG1234; Eukaryota.
DR   GeneTree; ENSGT00940000169293; -.
DR   HOGENOM; CLU_006533_9_1_1; -.
DR   InParanoid; Q18486; -.
DR   OMA; LEMGNVH; -.
DR   OrthoDB; 525494at2759; -.
DR   PhylomeDB; Q18486; -.
DR   UniPathway; UPA00232; -.
DR   PRO; PR:Q18486; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000767; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IMP:WormBase.
DR   CDD; cd13970; ABC1_ADCK3; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR034646; ADCK3_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Mitochondrion; Nucleotide-binding; Reference proteome;
KW   Transferase; Transit peptide; Ubiquinone biosynthesis.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           ?..755
FT                   /note="Atypical kinase coq-8, mitochondrial"
FT                   /id="PRO_0000200698"
FT   REGION          57..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        587
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         435..443
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         457
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   755 AA;  83615 MW;  B5BDAF882A901416 CRC64;
     MAAKRPPAST LKWCQQEMGP ICEGIGMVVR SQIGYDGRRI EKQIRRKALQ TVVMGGQDVD
     PLKEPNKTNA PLLSPTLPST NEALQRARVV AAGIETFAKL MSQGTYPGSA GFTVSETGER
     KYMKQTSPVQ SNIVANLMAT ADKLSKGVIS LAPFPLPTIT KLGTWVIANP TAQLPIPPQL
     KSAIPAIGQI ETLIQSILGV QGPVSSVSRA PRKLKLEGVT DQVVLEPETI HATVDVEPID
     KTLTKEEAEF LIKAARSVDD DNAETAIFGT QKAKPKVYRP ELPKNFEVNL EMGNVHTLTR
     SNESSVPATR IGRLATFGQL AFGLLGGATA EVTRRTFGIG KRLQEEGIPK NPFLSEANAD
     RIVATLCRVR GAALKLGQML SIQDSSTVPP ALLQIFERVR QSADFMPIKQ VHRQMKDAFG
     DDWREKFEHF DDKPFACASI GQVHKAVLKD GRNVAVKVQY PGVAEGIDSD IDNLVSVLSV
     GGIFPKGMFL DAFVGVARRE LKQECDYERE ARAMKKFREL IADWQDVYVP EVIDELSSSR
     VLTTELVYGK PVDACVEEPQ VVRDYIAGKF IELCLKEIFL WRFMQTDPNW SNFFLGKHPK
     TGEPRLVLLD FGASRAYGKK FVDIYMNIIK SAYDGDKKKI IEYSREIGFL TGYETSVMED
     AHVESVMIMG ETLASNHPYN FANQDVTMRI QKLIPVMLEH RLTSPPEEIY SLHRKLSGCY
     LLAAKLKATV SCGGLFHEIH ENYVFGEDGI DINID