ID   COQ9_BOVIN              Reviewed;         319 AA.
AC   Q2NL34;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Ubiquinone biosynthesis protein COQ9, mitochondrial;
DE   Flags: Precursor;
GN   Name=COQ9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lipid-binding protein involved in the biosynthesis of
CC       coenzyme Q, also named ubiquinone, an essential lipid-soluble electron
CC       transporter for aerobic cellular respiration. Binds a phospholipid of
CC       at least 10 carbons in each acyl group. May be required to present its
CC       bound-lipid to COQ7. {ECO:0000250|UniProtKB:O75208}.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000250|UniProtKB:Q8K1Z0}.
CC   -!- SUBUNIT: Homodimer. Interacts with COQ7.
CC       {ECO:0000250|UniProtKB:O75208}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8K1Z0}.
CC   -!- DOMAIN: Structurally similar to the bacterial FadR protein (fatty acid
CC       metabolism regulator protein). {ECO:0000250|UniProtKB:O75208}.
CC   -!- SIMILARITY: Belongs to the COQ9 family. {ECO:0000305}.
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DR   EMBL; BC111144; AAI11145.1; -; mRNA.
DR   RefSeq; NP_001039767.1; NM_001046302.2.
DR   AlphaFoldDB; Q2NL34; -.
DR   SMR; Q2NL34; -.
DR   STRING; 9913.ENSBTAP00000002419; -.
DR   PaxDb; Q2NL34; -.
DR   PeptideAtlas; Q2NL34; -.
DR   PRIDE; Q2NL34; -.
DR   Ensembl; ENSBTAT00000002419; ENSBTAP00000002419; ENSBTAG00000001855.
DR   GeneID; 529282; -.
DR   KEGG; bta:529282; -.
DR   CTD; 57017; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001855; -.
DR   VGNC; VGNC:27618; COQ9.
DR   eggNOG; KOG2969; Eukaryota.
DR   GeneTree; ENSGT00390000009328; -.
DR   HOGENOM; CLU_057411_0_2_1; -.
DR   InParanoid; Q2NL34; -.
DR   OMA; WFLAGDK; -.
DR   OrthoDB; 1304924at2759; -.
DR   TreeFam; TF324653; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000001855; Expressed in corpus luteum and 105 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0110142; C:ubiquinone biosynthesis complex; IEA:Ensembl.
DR   GO; GO:0008289; F:lipid binding; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR013718; COQ9.
DR   InterPro; IPR012762; Ubiq_biosynth_COQ9.
DR   PANTHER; PTHR21427; PTHR21427; 1.
DR   Pfam; PF08511; COQ9; 1.
DR   TIGRFAMs; TIGR02396; diverge_rpsU; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Lipid-binding; Mitochondrion; Reference proteome;
KW   Transit peptide; Ubiquinone biosynthesis.
FT   TRANSIT         1..45
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           46..319
FT                   /note="Ubiquinone biosynthesis protein COQ9, mitochondrial"
FT                   /id="PRO_0000228636"
FT   REGION          46..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         242..245
FT                   /ligand="1,2-diacylglycero-3-phosphoethanolamine"
FT                   /ligand_id="ChEBI:CHEBI:57613"
FT                   /evidence="ECO:0000250|UniProtKB:O75208"
FT   MOD_RES         176
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K1Z0"
SQ   SEQUENCE   319 AA;  35778 MW;  EA9DF30C8066B55B CRC64;
     MAATVAFSGV LRRAGWRLLQ LRCLPVPRCR PALAPRAFRA SAMQLRSLDQ QKDQPPPSSS
     QQQSEAQGAE EPNPEALRSP PRYTDQGGEE EEDYESEEQL QHRILTAALE FVPTHGWTAE
     AIAEGAQSLG LSSAAASMFG DDGSELILHF VTQCNARLTH VLEEEQKLVQ LGQAEKKKTD
     KFLRDAVETR LRMLIPYIQH WPRAFSILML PHNIPPSLNL LTSMVDDMWH YAGDQSTDFN
     WYTRRAVLAG IYNTTELVMM QDSSPDFEDT WRFLENRISD AMNMGHTAKQ VKSTGEALVQ
     GLMGAAVTLK NLTGLNQRR